Functional consequences in metabolic pathways from phylogenetic profiles

Yonatan Bilu; Michal Linial

doi:10.1007/3-540-45784-4_20

Functional consequences in metabolic pathways from phylogenetic profiles

Yonatan Bilu, Michal Linial

Department of Biological Chemistry

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Phylogenetic profiling is an ingenious computational method for identifying functional linkage between proteins. It is based on the assumption that a set of proteins involved in a common pathway or composing a structural complex tends to evolve in a correlated fashion. We present a rigorous statistical analysis of the success of this method in identifying proteins involved in the same metabolic pathway. We suggest several modifications for the use of phylogenetic profiles that improve the success measure significantly. The potential and the limitations of this method for protein functional predictions are discussed.

Original language	American English
Title of host publication	Algorithms in Bioinformatics - 2nd International Workshop,WABI 2002, Proceedings
Editors	Roderic Guigo, Dan Gusfield
Publisher	Springer Verlag
Pages	23-276
Number of pages	254
ISBN (Print)	3540442111, 9783540442110
DOIs	https://doi.org/10.1007/3-540-45784-4_20
State	Published - 2002
Event	2nd International Workshop on Algorithms in Bioinformatics, WABI 2002 - Rome, Italy Duration: 17 Sep 2002 → 21 Sep 2002

Publication series

Name	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume	2452
ISSN (Print)	0302-9743
ISSN (Electronic)	1611-3349

Conference

Conference	2nd International Workshop on Algorithms in Bioinformatics, WABI 2002
Country/Territory	Italy
City	Rome
Period	17/09/02 → 21/09/02

Bibliographical note

Publisher Copyright:
© Springer-Verlag Berlin Heidelberg 2002.

Access to Document

10.1007/3-540-45784-4_20

Cite this

Bilu, Y., & Linial, M. (2002). Functional consequences in metabolic pathways from phylogenetic profiles. In R. Guigo, & D. Gusfield (Eds.), Algorithms in Bioinformatics - 2nd International Workshop,WABI 2002, Proceedings (pp. 23-276). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 2452). Springer Verlag. https://doi.org/10.1007/3-540-45784-4_20

Bilu, Yonatan ; Linial, Michal. / Functional consequences in metabolic pathways from phylogenetic profiles. Algorithms in Bioinformatics - 2nd International Workshop,WABI 2002, Proceedings. editor / Roderic Guigo ; Dan Gusfield. Springer Verlag, 2002. pp. 23-276 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).

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Bilu, Y & Linial, M 2002, Functional consequences in metabolic pathways from phylogenetic profiles. in R Guigo & D Gusfield (eds), Algorithms in Bioinformatics - 2nd International Workshop,WABI 2002, Proceedings. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 2452, Springer Verlag, pp. 23-276, 2nd International Workshop on Algorithms in Bioinformatics, WABI 2002, Rome, Italy, 17/09/02. https://doi.org/10.1007/3-540-45784-4_20

Functional consequences in metabolic pathways from phylogenetic profiles. / Bilu, Yonatan; Linial, Michal.
Algorithms in Bioinformatics - 2nd International Workshop,WABI 2002, Proceedings. ed. / Roderic Guigo; Dan Gusfield. Springer Verlag, 2002. p. 23-276 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 2452).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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Bilu Y, Linial M. Functional consequences in metabolic pathways from phylogenetic profiles. In Guigo R, Gusfield D, editors, Algorithms in Bioinformatics - 2nd International Workshop,WABI 2002, Proceedings. Springer Verlag. 2002. p. 23-276. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). doi: 10.1007/3-540-45784-4_20

Functional consequences in metabolic pathways from phylogenetic profiles

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