Functional defects in the external and internal thin gates of the γ-aminobutyric acid (GABA) transporter GAT-1 can compensate each other

Assaf Ben-Yona, Baruch I. Kanner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Background: Mutations in "thin" extra-and intracellular gates of GAT-1 impair gating and transport. Results: Transport activity of extracellular gate mutant can be rescued by its intracellular counterpart. Conclusion: A functional interaction of the external and internal gates of GAT-1 is essential for transport. Significance: The new insights into GAT-1 gating may be relevant for other transporters.

Original languageEnglish
Pages (from-to)4549-4556
Number of pages8
JournalJournal of Biological Chemistry
Volume288
Issue number7
DOIs
StatePublished - 15 Feb 2013

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