Abstract
Background: Mutations in "thin" extra-and intracellular gates of GAT-1 impair gating and transport. Results: Transport activity of extracellular gate mutant can be rescued by its intracellular counterpart. Conclusion: A functional interaction of the external and internal gates of GAT-1 is essential for transport. Significance: The new insights into GAT-1 gating may be relevant for other transporters.
Original language | English |
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Pages (from-to) | 4549-4556 |
Number of pages | 8 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 7 |
DOIs | |
State | Published - 15 Feb 2013 |