Functional efficacy of glatiramer acetate treatment for laser-induced retinal damage in rats

Mark Belokopytov, Gil Ben-Shlomo, Mordechai Rosner, Michael Belkin*, Galina Dubinski, Yoram Epstein, Ron Ofri

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Background and Objectives: To functionally evaluate the efficacy of glatiramer acetate (Cop-1) as a neuroprotective treatment for laser-induced retinal injuries in rats. Study Design/Materials and Methods: Using standard lasering and flash ERG techniques, we evaluated the effect of photocoagulation and of Cop-1 treatment on retinal function 3, 20, and 60 days after covering one-half of the retina with of 23 rats with argon laser lesions. Results: Significant neuroprotective effects of Cop-1 treatment on functional recovery were observed 20 and 60 days after retinal photocoagulation. Two months post-lasering, the amplitude of electroretinographic signals in lasered eyes (mean ± SEM) was 99.5 ± 10.2% of that of intact eyes in the Cop-1-treated group and 85.8 ± 5.5% in the untreated lasered control group (P<0.05). Conclusions: Cop-1 immunization in rats is neuroprotective against laser-induced injuries to the outer retina and improves functional recovery of the injured retina. Studies have documented effective neuroprotective treatment after laser damage to myelinated neurons, but this is the first report of neuroprotection of nonmyelinated neurons.

Original languageAmerican English
Pages (from-to)196-201
Number of pages6
JournalLasers in Surgery and Medicine
Volume40
Issue number3
DOIs
StatePublished - Mar 2008

Keywords

  • Electroretinogram
  • Laser
  • Neuroprotection
  • Retinal injury
  • Wound healing

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