Functional organization of ferret auditory cortex

Jennifer K. Bizley, Fernando R. Nodal, Israel Nelken, Andrew J. King*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

157 Scopus citations

Abstract

We characterized the functional organization of different fields within the auditory cortex of anaesthetized ferrets. As previously reported, the primary auditory cortex, A1, and the anterior auditory field, AAF, are located on the middle ectosylvian gyrus. These areas exhibited a similar tonotopic organization, with high frequencies represented at the dorsal tip of the gyrus and low frequencies more ventrally, but differed in that AAF neurons had shorter response latencies than those in A1. On the basis of differences in frequency selectivity, temporal response properties and thresholds, we identified four more, previously undescribed fields. Two of these are located on the posterior ectosylvian gyrus and were tonotopically organized. Neurons in these areas responded robustly to tones, but had longer latencies, more sustained responses and a higher incidence of non-monotonic rate-level functions than those in the primary fields. Two further auditory fields, which were not tonotopically organized, were found on the anterior ectosylvian gyrus. Neurons in the more dorsal anterior area gave short-latency, transient responses to tones and were generally broadly tuned with a preference for high (>8 kHz) frequencies. Neurons in the other anterior area were frequently unresponsive to tones, but often responded vigorously to broadband noise. The presence of both tonotopic and non-tonotopic auditory cortical fields indicates that the organization of ferret auditory cortex is comparable to that seen in other mammals.

Original languageAmerican English
Pages (from-to)1637-1653
Number of pages17
JournalCerebral Cortex
Volume15
Issue number10
DOIs
StatePublished - Oct 2005

Bibliographical note

Funding Information:
This work was funded by a Wellcome Trust studentship and a travel grant from the Interdisciplinary Center for Neural Computation of the Hebrew University (J.K.B.) and by a Wellcome Senior Research Fellowship (A.J.K.). I.N. was supported by the ISF. We are grateful to Victoria Bajo and Dina Farkas for valuable discussion.

Keywords

  • Cortical field
  • Ectosylvian gyrus
  • Electrophysiology
  • Frequency tuning
  • Non-primary
  • Tonotopic

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