TY - JOUR
T1 - Functional polymeric nerve guidance conduits and drug delivery strategies for peripheral nerve repair and regeneration
AU - Manoukian, Ohan S.
AU - Baker, Jiana T.
AU - Rudraiah, Swetha
AU - Arul, Michael R.
AU - Vella, Anthony T.
AU - Domb, Abraham J.
AU - Kumbar, Sangamesh G.
N1 - Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2020/1/10
Y1 - 2020/1/10
N2 - Peripheral nerve injuries can be extremely debilitating, resulting in sensory and motor loss-of-function. Endogenous repair is limited to non-severe injuries in which transection of nerves necessitates surgical intervention. Traditional treatment approaches include the use of biological grafts and alternative engineering approaches have made progress. The current article serves as a comprehensive, in-depth perspective on peripheral nerve regeneration, particularly nerve guidance conduits and drug delivery strategies. A detailed background of peripheral nerve injury and repair pathology, and an in-depth look into augmented nerve regeneration, nerve guidance conduits, and drug delivery strategies provide a state-of-the-art perspective on the field.
AB - Peripheral nerve injuries can be extremely debilitating, resulting in sensory and motor loss-of-function. Endogenous repair is limited to non-severe injuries in which transection of nerves necessitates surgical intervention. Traditional treatment approaches include the use of biological grafts and alternative engineering approaches have made progress. The current article serves as a comprehensive, in-depth perspective on peripheral nerve regeneration, particularly nerve guidance conduits and drug delivery strategies. A detailed background of peripheral nerve injury and repair pathology, and an in-depth look into augmented nerve regeneration, nerve guidance conduits, and drug delivery strategies provide a state-of-the-art perspective on the field.
KW - Biomaterials
KW - Drug delivery
KW - Nerve guidance conduits
KW - Neural tissue engineering
KW - Peripheral nerve injury
UR - http://www.scopus.com/inward/record.url?scp=85075365818&partnerID=8YFLogxK
U2 - 10.1016/j.jconrel.2019.11.021
DO - 10.1016/j.jconrel.2019.11.021
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C2 - 31756394
AN - SCOPUS:85075365818
SN - 0168-3659
VL - 317
SP - 78
EP - 95
JO - Journal of Controlled Release
JF - Journal of Controlled Release
ER -