Functional Properties of Cortical Feedback Projections to the Olfactory Bulb

Foivos Markopoulos, Dan Rokni, David H. Gire, Venkatesh N. Murthy*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

166 Scopus citations

Abstract

Sensory perception is not a simple feed-forward process, and higher brain areas can actively modulate information processing in " lower" areas. We used optogenetic methods to examine how cortical feedback projections affect circuits in the first olfactory processing stage, the olfactory bulb. Selective activation of back projections from the anterior olfactory nucleus/cortex (AON) revealed functional glutamatergic synaptic connections on several types of bulbar interneurons. Unexpectedly, AON axons also directly depolarized mitral cells (MCs), enough to elicit spikes reliably in a time window of a few milliseconds. MCs received strong disynaptic inhibition, a third of which arises in the glomerular layer. Activating feedback axons in vivo suppressed spontaneous as well as odor-evoked activity of MCs, sometimes preceded by a temporally precise increase in firing probability. Our study indicates that cortical feedback can shape the activity of bulbar output neurons by enabling precisely timed spikes and enforcing broad inhibition to suppress background activity.

Original languageAmerican English
Pages (from-to)1175-1188
Number of pages14
JournalNeuron
Volume76
Issue number6
DOIs
StatePublished - 20 Dec 2012
Externally publishedYes

Bibliographical note

Funding Information:
F.M. was supported by a Swiss National Foundation Fellowship and D.R. was supported by the Edmond and Lily Safra Center for Brain Sciences, Hebrew University. Work in V.N.M.’s laboratory related to this project was supported by Harvard University and by the NIH. We thank the Harvard Center for Biological Imaging and Professor Catherine Dulac for the use of microscopes to image fixed tissue.

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