Further evidence for the interaction of the antimalarial drug amodiaquine with ferriprotoporphyrin IX

Gideon Blauer; Muataz Akkawi; Erika R. Bauminger

doi:10.1016/0006-2952(93)90325-Q

Further evidence for the interaction of the antimalarial drug amodiaquine with ferriprotoporphyrin IX

Gideon Blauer^*, Muataz Akkawi, Erika R. Bauminger

^*Corresponding author for this work

Racah Institute of Physics

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Evidence for complex formation of the antimalarial drug amodiaquine (AD) with ferriprotoporphyrin IX (FP) in aqueous medium is presented, in addition to previous preliminary data. A mole ratio of one between the complex components is determined for the insoluble complex at pH 6.7-6.8. Mössbauer data obtained at pH 7-8 and at higher concentrations in the millimolar range confirm the interactions existing between the complex components. These data are considered to aid in removing previous objections to a mechanism of antimalarial action involving complexes of FP with AD and related drugs.

Original language	English
Pages (from-to)	1573-1576
Number of pages	4
Journal	Biochemical Pharmacology
Volume	46
Issue number	9
DOIs	https://doi.org/10.1016/0006-2952(93)90325-Q
State	Published - 2 Nov 1993

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abstract = "Evidence for complex formation of the antimalarial drug amodiaquine (AD) with ferriprotoporphyrin IX (FP) in aqueous medium is presented, in addition to previous preliminary data. A mole ratio of one between the complex components is determined for the insoluble complex at pH 6.7-6.8. M{\"o}ssbauer data obtained at pH 7-8 and at higher concentrations in the millimolar range confirm the interactions existing between the complex components. These data are considered to aid in removing previous objections to a mechanism of antimalarial action involving complexes of FP with AD and related drugs.",

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AU - Bauminger, Erika R.

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N2 - Evidence for complex formation of the antimalarial drug amodiaquine (AD) with ferriprotoporphyrin IX (FP) in aqueous medium is presented, in addition to previous preliminary data. A mole ratio of one between the complex components is determined for the insoluble complex at pH 6.7-6.8. Mössbauer data obtained at pH 7-8 and at higher concentrations in the millimolar range confirm the interactions existing between the complex components. These data are considered to aid in removing previous objections to a mechanism of antimalarial action involving complexes of FP with AD and related drugs.

AB - Evidence for complex formation of the antimalarial drug amodiaquine (AD) with ferriprotoporphyrin IX (FP) in aqueous medium is presented, in addition to previous preliminary data. A mole ratio of one between the complex components is determined for the insoluble complex at pH 6.7-6.8. Mössbauer data obtained at pH 7-8 and at higher concentrations in the millimolar range confirm the interactions existing between the complex components. These data are considered to aid in removing previous objections to a mechanism of antimalarial action involving complexes of FP with AD and related drugs.

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Further evidence for the interaction of the antimalarial drug amodiaquine with ferriprotoporphyrin IX

Abstract

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