Further studies on the differences in serum dependence in EBV negative lymphoma lines and their in vitro EBV converted, virus-genome carrying sublines

Michael Steinitz*, George Klein

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Independently EBV-converted, viral genome carrying sublines of the originally EBV negative Ramos and BJAB lymphoma lines showed decreased serum dependence, in comparison with the progenitor lines. The virus negative lines could not grow in 10% dialysed FCS, unless reconstituted with the dialysate. The converted lines grew well on dialysed serum. Seeding of the EBV negative lines with larger inocula enabled them to "take off" on dialysed serum as well. The EBV converted lines were able to form colonies in soft agar, whereas the original negative lines failed to do so.

Original languageEnglish
Pages (from-to)1269-1275
Number of pages7
JournalEuropean Journal of Cancer (1965)
Volume13
Issue number11
DOIs
StatePublished - Nov 1977
Externally publishedYes

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