Abstract
Accumulating evidence demonstrates that the oral pathobiont Fusobacterium nucleatum is involved in the progression of an increasing number of tumors types. Thus far, the mechanisms underlying tumor exacerbation by F. nucleatum include the enhancement of proliferation, establishment of a tumor-promoting immune environment, induction of chemoresistance, and the activation of immune checkpoints. This review focuses on the mechanisms that mediate tumor-specific colonization by fusobacteria. Elucidating the mechanisms mediating fusobacterial tumor tropism and promotion might provide new insights for the development of novel approaches for tumor detection and treatment.
| Original language | American English |
|---|---|
| Pages (from-to) | 166-180 |
| Number of pages | 15 |
| Journal | Periodontology 2000 |
| Volume | 89 |
| Issue number | 1 |
| Early online date | 4 Mar 2022 |
| DOIs | |
| State | Published - Jun 2022 |
Bibliographical note
Funding Information:This work was supported by the Israel Cancer Research Fund Project grant (GB), the Israel Science Foundation Moked grant and the Israel Ministry of Science and Technology Personalized Medicine grant (GB and OM). TAM is a fellow of the AdR Women Doctoral Program. Figures were created using BioRender.com.
Publisher Copyright:
© 2022 The Authors. Periodontology 2000 published by John Wiley & Sons Ltd.
Keywords
- Fusobacterium nucleatum
- oncobacteria
- oncobiont
- pathobiont
