Fusobacterium nucleatum and cancer

Tamar Alon-Maimon, Ofer Mandelboim*, Gilad Bachrach*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations

Abstract

Accumulating evidence demonstrates that the oral pathobiont Fusobacterium nucleatum is involved in the progression of an increasing number of tumors types. Thus far, the mechanisms underlying tumor exacerbation by F. nucleatum include the enhancement of proliferation, establishment of a tumor-promoting immune environment, induction of chemoresistance, and the activation of immune checkpoints. This review focuses on the mechanisms that mediate tumor-specific colonization by fusobacteria. Elucidating the mechanisms mediating fusobacterial tumor tropism and promotion might provide new insights for the development of novel approaches for tumor detection and treatment.

Original languageAmerican English
Pages (from-to)166-180
Number of pages15
JournalPeriodontology 2000
Volume89
Issue number1
DOIs
StatePublished - Jun 2022

Bibliographical note

Publisher Copyright:
© 2022 The Authors. Periodontology 2000 published by John Wiley & Sons Ltd.

Keywords

  • Fusobacterium nucleatum
  • oncobacteria
  • oncobiont
  • pathobiont

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