G-protein subunit dissociation is not an integral part of G-protein action

Alexander Levitzki; Shoshana Klein

doi:10.1002/1439-7633(20020902)3:9<815::AID-CBIC815>3.0.CO;2-E

G-protein subunit dissociation is not an integral part of G-protein action

Alexander Levitzki^*
, Shoshana Klein

^*Corresponding author for this work

Alexander Silberman Institute of Life Sciences

Research output: Contribution to journal › Short survey › peer-review

46 Scopus citations

Abstract

Challenging the dogma: The textbook model for activation of heterotrimeric G proteins is reexamined in this minireview. Subunit dissociation has only been demonstrated directly for transducin. Other G proteins may remain closely associated in multiprotein complexes, with activation involving a conformational change.

Original language	English
Pages (from-to)	815-818
Number of pages	4
Journal	ChemBioChem
Volume	3
Issue number	9
DOIs	https://doi.org/10.1002/1439-7633(20020902)3:9<815::AID-CBIC815>3.0.CO;2-E
State	Published - 2002

Keywords

G proteins
Signal transduction
Subunit dissociation

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10.1002/1439-7633(20020902)3:9<815::AID-CBIC815>3.0.CO;2-E

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title = "G-protein subunit dissociation is not an integral part of G-protein action",

abstract = "Challenging the dogma: The textbook model for activation of heterotrimeric G proteins is reexamined in this minireview. Subunit dissociation has only been demonstrated directly for transducin. Other G proteins may remain closely associated in multiprotein complexes, with activation involving a conformational change.",

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AU - Klein, Shoshana

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AB - Challenging the dogma: The textbook model for activation of heterotrimeric G proteins is reexamined in this minireview. Subunit dissociation has only been demonstrated directly for transducin. Other G proteins may remain closely associated in multiprotein complexes, with activation involving a conformational change.

KW - G proteins

KW - Signal transduction

KW - Subunit dissociation

UR - https://www.scopus.com/pages/publications/0036905936

U2 - 10.1002/1439-7633(20020902)3:9<815::AID-CBIC815>3.0.CO;2-E

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G-protein subunit dissociation is not an integral part of G-protein action

Abstract

Keywords

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