GABA influences rabbit corneal deturgescence

R. Vidal*, A. Wendel, O. Neuwirth, S. Dikstein

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

GABA and its analogues were shown to stimulate the rabbit corneal endothelial fluid pump in the micromolar range. GABA increases the rate of fluid pumping when added to the basic salt solution. The stimulation was abolished by bicuculline and chlorpromazine. The efficacy of GABA and the survival time markedly increased in the presence of insulin and glucose, in presumably physiological concentrations. Complete reversal and survival up to 8 hours is obtained by GABA-glucose-insulin combination, whereas the glutathione-glucose-insulin combination is not efficient.

Original languageEnglish
Pages (from-to)485-486
Number of pages2
JournalBrain Research Bulletin
Volume5
Issue numberSUPPL. 2
DOIs
StatePublished - 1980

Keywords

  • Endothelial pump
  • GABA
  • Glucose Insulin
  • Rabbit corneal

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