GABA transport goes structural

Baruch I. Kanner; Oshrat Dayan-Alon

doi:10.1016/j.tips.2022.08.001

GABA transport goes structural

Baruch I. Kanner^*
, Oshrat Dayan-Alon

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Short survey › peer-review

6 Scopus citations

Abstract

The γ-aminobutyric acid transporter 1 (GAT1) is a transporter which clears the inhibitory neurotransmitter γ-aminobutyric acid (GABA) from the synaptic cleft. The paper by Motiwala et al. documents a structure of GAT1 in complex with the antiepileptic drug tiagabine. This study will enable structure-based docking of large chemical libraries for the discovery of novel antiepileptics.

Original language	English
Pages (from-to)	4-6
Number of pages	3
Journal	Trends in Pharmacological Sciences
Volume	44
Issue number	1
DOIs	https://doi.org/10.1016/j.tips.2022.08.001
State	Published - Jan 2023

Bibliographical note

Publisher Copyright:
© 2022 Elsevier Ltd

Keywords

alternating access
cryo-EM
neurotransmitter:sodium:symporter
two-step inhibition mechanism

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10.1016/j.tips.2022.08.001

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KW - cryo-EM

KW - neurotransmitter:sodium:symporter

KW - two-step inhibition mechanism

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GABA transport goes structural

Abstract

Bibliographical note

Keywords

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