Gain-of-function genetic alterations of g9a drive oncogenesis

Shinichiro Kato; Qing Yu Weng; Megan L. Insco; Kevin Y. Chen; Sathya Muralidhar; Joanna Pozniak; Joey Mark S. Diaz; Yotam Drier; Nhu Nguyen; Jennifer A. Lo; Ellen van Rooijen; Lajos V. Kemeny; Yao Zhan; Yang Feng; Whitney Silkworth; C. Thomas Powell; Brian B. Liau; Yan Xiong; Jian Jin; Julia Newton-Bishop; Leonard I. Zon; Bradley E. Bernstein; David E. Fisher

doi:10.1158/2159-8290.CD-19-0532

Gain-of-function genetic alterations of g9a drive oncogenesis

Shinichiro Kato, Qing Yu Weng, Megan L. Insco, Kevin Y. Chen, Sathya Muralidhar, Joanna Pozniak, Joey Mark S. Diaz, Yotam Drier, Nhu Nguyen, Jennifer A. Lo, Ellen van Rooijen, Lajos V. Kemeny, Yao Zhan, Yang Feng, Whitney Silkworth, C. Thomas Powell, Brian B. Liau, Yan Xiong, Jian Jin, Julia Newton-BishopLeonard I. Zon, Bradley E. Bernstein, David E. Fisher^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

SIGNIFICANCE: Oncogenic G9a abnormalities drive tumorigenesis and the “cold” immune microenvi-ronment by activating WNT signaling through DKK1 repression. These results reveal a key druggable mechanism for tumor development and identify strategies to restore “hot” tumor immune microenvi-ronments.

Original language	English
Pages (from-to)	980-997
Number of pages	18
Journal	Cancer Discovery
Volume	10
Issue number	7
DOIs	https://doi.org/10.1158/2159-8290.CD-19-0532
State	Published - Jul 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 American Association for Cancer Research.

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10.1158/2159-8290.CD-19-0532

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Kato, S., Weng, Q. Y., Insco, M. L., Chen, K. Y., Muralidhar, S., Pozniak, J., Diaz, J. M. S., Drier, Y., Nguyen, N., Lo, J. A., van Rooijen, E., Kemeny, L. V., Zhan, Y., Feng, Y., Silkworth, W., Powell, C. T., Liau, B. B., Xiong, Y., Jin, J., ... Fisher, D. E. (2020). Gain-of-function genetic alterations of g9a drive oncogenesis. Cancer Discovery, 10(7), 980-997. https://doi.org/10.1158/2159-8290.CD-19-0532

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title = "Gain-of-function genetic alterations of g9a drive oncogenesis",

abstract = "SIGNIFICANCE: Oncogenic G9a abnormalities drive tumorigenesis and the “cold” immune microenvi-ronment by activating WNT signaling through DKK1 repression. These results reveal a key druggable mechanism for tumor development and identify strategies to restore “hot” tumor immune microenvi-ronments.",

author = "Shinichiro Kato and Weng, {Qing Yu} and Insco, {Megan L.} and Chen, {Kevin Y.} and Sathya Muralidhar and Joanna Pozniak and Diaz, {Joey Mark S.} and Yotam Drier and Nhu Nguyen and Lo, {Jennifer A.} and {van Rooijen}, Ellen and Kemeny, {Lajos V.} and Yao Zhan and Yang Feng and Whitney Silkworth and Powell, {C. Thomas} and Liau, {Brian B.} and Yan Xiong and Jian Jin and Julia Newton-Bishop and Zon, {Leonard I.} and Bernstein, {Bradley E.} and Fisher, {David E.}",

note = "Publisher Copyright: {\textcopyright} 2020 American Association for Cancer Research.",

year = "2020",

month = jul,

doi = "10.1158/2159-8290.CD-19-0532",

language = "אנגלית",

volume = "10",

pages = "980--997",

journal = "Cancer Discovery",

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Kato, S, Weng, QY, Insco, ML, Chen, KY, Muralidhar, S, Pozniak, J, Diaz, JMS, Drier, Y, Nguyen, N, Lo, JA, van Rooijen, E, Kemeny, LV, Zhan, Y, Feng, Y, Silkworth, W, Powell, CT, Liau, BB, Xiong, Y, Jin, J, Newton-Bishop, J, Zon, LI, Bernstein, BE & Fisher, DE 2020, 'Gain-of-function genetic alterations of g9a drive oncogenesis', Cancer Discovery, vol. 10, no. 7, pp. 980-997. https://doi.org/10.1158/2159-8290.CD-19-0532

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AU - Kato, Shinichiro

AU - Weng, Qing Yu

AU - Insco, Megan L.

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AU - Muralidhar, Sathya

AU - Pozniak, Joanna

AU - Diaz, Joey Mark S.

AU - Drier, Yotam

AU - Nguyen, Nhu

AU - Lo, Jennifer A.

AU - van Rooijen, Ellen

AU - Kemeny, Lajos V.

AU - Zhan, Yao

AU - Feng, Yang

AU - Silkworth, Whitney

AU - Powell, C. Thomas

AU - Liau, Brian B.

AU - Xiong, Yan

AU - Jin, Jian

AU - Newton-Bishop, Julia

AU - Zon, Leonard I.

AU - Bernstein, Bradley E.

AU - Fisher, David E.

PY - 2020/7

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Gain-of-function genetic alterations of g9a drive oncogenesis

Abstract

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