Gain-of-function genetic alterations of g9a drive oncogenesis

Shinichiro Kato, Qing Yu Weng, Megan L. Insco, Kevin Y. Chen, Sathya Muralidhar, Joanna Pozniak, Joey Mark S. Diaz, Yotam Drier, Nhu Nguyen, Jennifer A. Lo, Ellen van Rooijen, Lajos V. Kemeny, Yao Zhan, Yang Feng, Whitney Silkworth, C. Thomas Powell, Brian B. Liau, Yan Xiong, Jian Jin, Julia Newton-BishopLeonard I. Zon, Bradley E. Bernstein, David E. Fisher*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

SIGNIFICANCE: Oncogenic G9a abnormalities drive tumorigenesis and the “cold” immune microenvi-ronment by activating WNT signaling through DKK1 repression. These results reveal a key druggable mechanism for tumor development and identify strategies to restore “hot” tumor immune microenvi-ronments.

Original languageAmerican English
Pages (from-to)980-997
Number of pages18
JournalCancer Discovery
Volume10
Issue number7
DOIs
StatePublished - Jul 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2020 American Association for Cancer Research.

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