Gamma-aminobutyric acid (GABA) in the CSF of schizophrenic patients before and after neuroleptic treatment

D Lichtshtein; J Dobkin; R P Ebstein; J Biederman; R Rimon; R H Belmaker

doi:10.1192/bjp.132.2.145

Gamma-aminobutyric acid (GABA) in the CSF of schizophrenic patients before and after neuroleptic treatment

D Lichtshtein, J Dobkin, R P Ebstein, J Biederman, R Rimon, R H Belmaker

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Gamma-aminobutyric acid (GABA) levels in the CSF were measured in 9 normal individuals, 17 drug-free schizophrenic patients and 10 of these same schizophrenic patients after neuroleptic treatment. There was no significant difference between CSF level of GABA in the control group compared to those in schizophrenic patients; however, 6 of the 7 lowest GABA levels were from schizophrenic patients. There was a significant decline of 12 per cent in mean GABA levels in the CSF after a mean of two months of neuroleptic treatment.

Original language	English
Pages (from-to)	145-8
Number of pages	4
Journal	The Journal of mental science
Volume	132
Issue number	2
DOIs	https://doi.org/10.1192/bjp.132.2.145
State	Published - Feb 1978

Keywords

Adult
Aminobutyrates/cerebrospinal fluid
Female
Humans
Male
Middle Aged
Schizophrenia/cerebrospinal fluid
Tranquilizing Agents/therapeutic use
gamma-Aminobutyric Acid/cerebrospinal fluid

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10.1192/bjp.132.2.145

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title = "Gamma-aminobutyric acid (GABA) in the CSF of schizophrenic patients before and after neuroleptic treatment",

abstract = "Gamma-aminobutyric acid (GABA) levels in the CSF were measured in 9 normal individuals, 17 drug-free schizophrenic patients and 10 of these same schizophrenic patients after neuroleptic treatment. There was no significant difference between CSF level of GABA in the control group compared to those in schizophrenic patients; however, 6 of the 7 lowest GABA levels were from schizophrenic patients. There was a significant decline of 12 per cent in mean GABA levels in the CSF after a mean of two months of neuroleptic treatment.",

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AU - Rimon, R

AU - Belmaker, R H

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Gamma-aminobutyric acid (GABA) in the CSF of schizophrenic patients before and after neuroleptic treatment

Abstract

Keywords

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