Gastric cancer metastases to the breast: systemic review and meta-analysis of the English literature

Harbi Khalayleh*, Raneem Bader, Ashraf Imam, Deeb Khoury, Ady Yosepovich, Barak Bar-Zakai, Tanir M. Allweis

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


INTRODUCTION: Gastric cancer (GC) metastasis to the breast is extremely rare. We report a case of a female patient with primary gastric carcinoma with breast metastasis and conduct an analysis and review of the English literature. EVIDENCE ACQUISITION: Literature databases including "ScienceDirect," "Springer," "PubMed" and "google scholar," were extensively searched up to 2021, using relevant keywords, such as: 'Stomach or gastric', 'tumor or cancer or carcinoma', 'breast or mammary' and "metastases". All the studies were reviewed, and the following information was extracted: gender, age, clinical presentation, histological type, time to breast metastasis, other sites of metastasis, management protocols, and survival. Only English studies were included. EVIDENCE SYNTHESIS: Atotal of 91 cases were eligible for the analysis. Of these, 74 (81.3%) were females, of whom were 4 pregnant. The mean age was 43.91. The most common histological subtype was Signet ring cell adenocarcinoma (SRCC) (48.35%). The most common tumor markers in cases of primary gastric cancer with breast metastasis were CK20, CK7, CEA, and CDX2. Mean survival was almost 6.6 months. CONCLUSIONS: GC metastasis to the breast is an uncommon event with a poor prognosis. Clinical history, diagnostic imaging, and anatomopathological and immunohistochemical examinations are important to distinguish metastatic cancer from primary breast cancer, allowing patients to receive appropriate treatment.

Original languageAmerican English
Pages (from-to)261-269
Number of pages9
JournalChirurgia (Turin)
Issue number5
StatePublished - 2023

Bibliographical note

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© 2023 Edizioni Minerva Medica. All rights reserved.


  • Breast neoplasms
  • Immunohistochemistry
  • Neoplasm metastasis
  • Stomach neoplasms


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