GC determination of N-nitrosamines by supersonic molecular beam MS equipped with triple quadrupole analyzer, GC/SMB/QQQ/MS

Voloshenko Anna; Shelkov Rimma; Ovadia Lev; Gun Jenny

doi:10.1016/j.aca.2010.11.026

GC determination of N-nitrosamines by supersonic molecular beam MS equipped with triple quadrupole analyzer, GC/SMB/QQQ/MS

Voloshenko Anna, Shelkov Rimma, Ovadia Lev^*, Gun Jenny

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The determination of 14 N-nitrosamines by a supersonic molecular beam electron ionization mass spectrometer equipped with triple quadruple analyzer, GC/SMB/EI/QQQ/MS is presented. The supersonic molecular beam electron ionization ion source allows the elucidation of the molecular ion of 13 out of the 14 examined nitrosamines (except for diphenylnitrosamine which was degraded before the analysis). It was possible to use the molecular ions of all the nitrosamines as the parent ions for multiple reactions monitoring mode, which in turn allows significant increase of specificity and lowering of the method limit of detection of the higher molecular weight nitrosamines. The instrumental LOD for different N-nitrosamines was 1-5pginjection^-1. The proposed method was exemplified by analysis of N-nitrosamines and N-nitrosatables in rubber teats according to the British Standard BS EN 12868:1999.

Original language	English
Pages (from-to)	162-169
Number of pages	8
Journal	Analytica Chimica Acta
Volume	685
Issue number	2
DOIs	https://doi.org/10.1016/j.aca.2010.11.026
State	Published - 31 Jan 2011

Bibliographical note

Funding Information:
The authors acknowledge financial support of the Israel Water Authority, the BMBF-Germany – MOST-Israel, Water Technology Program, The infrastructure research program of MOST, and the Environment and Health Fund. We thank A. Amirav from the Tel Aviv University and F.T Lange and M. Schuerer from TZW Karlsruhe for valuable discussions.

Keywords

N-nitrosamines
Soft ionization
Supersonic molecular beam

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10.1016/j.aca.2010.11.026

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title = "GC determination of N-nitrosamines by supersonic molecular beam MS equipped with triple quadrupole analyzer, GC/SMB/QQQ/MS",

abstract = "The determination of 14 N-nitrosamines by a supersonic molecular beam electron ionization mass spectrometer equipped with triple quadruple analyzer, GC/SMB/EI/QQQ/MS is presented. The supersonic molecular beam electron ionization ion source allows the elucidation of the molecular ion of 13 out of the 14 examined nitrosamines (except for diphenylnitrosamine which was degraded before the analysis). It was possible to use the molecular ions of all the nitrosamines as the parent ions for multiple reactions monitoring mode, which in turn allows significant increase of specificity and lowering of the method limit of detection of the higher molecular weight nitrosamines. The instrumental LOD for different N-nitrosamines was 1-5pginjection-1. The proposed method was exemplified by analysis of N-nitrosamines and N-nitrosatables in rubber teats according to the British Standard BS EN 12868:1999.",

keywords = "N-nitrosamines, Soft ionization, Supersonic molecular beam",

author = "Voloshenko Anna and Shelkov Rimma and Ovadia Lev and Gun Jenny",

note = "Funding Information: The authors acknowledge financial support of the Israel Water Authority, the BMBF-Germany – MOST-Israel, Water Technology Program, The infrastructure research program of MOST, and the Environment and Health Fund. We thank A. Amirav from the Tel Aviv University and F.T Lange and M. Schuerer from TZW Karlsruhe for valuable discussions.",

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doi = "10.1016/j.aca.2010.11.026",

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AU - Rimma, Shelkov

AU - Lev, Ovadia

AU - Jenny, Gun

N1 - Funding Information: The authors acknowledge financial support of the Israel Water Authority, the BMBF-Germany – MOST-Israel, Water Technology Program, The infrastructure research program of MOST, and the Environment and Health Fund. We thank A. Amirav from the Tel Aviv University and F.T Lange and M. Schuerer from TZW Karlsruhe for valuable discussions.

PY - 2011/1/31

Y1 - 2011/1/31

N2 - The determination of 14 N-nitrosamines by a supersonic molecular beam electron ionization mass spectrometer equipped with triple quadruple analyzer, GC/SMB/EI/QQQ/MS is presented. The supersonic molecular beam electron ionization ion source allows the elucidation of the molecular ion of 13 out of the 14 examined nitrosamines (except for diphenylnitrosamine which was degraded before the analysis). It was possible to use the molecular ions of all the nitrosamines as the parent ions for multiple reactions monitoring mode, which in turn allows significant increase of specificity and lowering of the method limit of detection of the higher molecular weight nitrosamines. The instrumental LOD for different N-nitrosamines was 1-5pginjection-1. The proposed method was exemplified by analysis of N-nitrosamines and N-nitrosatables in rubber teats according to the British Standard BS EN 12868:1999.

AB - The determination of 14 N-nitrosamines by a supersonic molecular beam electron ionization mass spectrometer equipped with triple quadruple analyzer, GC/SMB/EI/QQQ/MS is presented. The supersonic molecular beam electron ionization ion source allows the elucidation of the molecular ion of 13 out of the 14 examined nitrosamines (except for diphenylnitrosamine which was degraded before the analysis). It was possible to use the molecular ions of all the nitrosamines as the parent ions for multiple reactions monitoring mode, which in turn allows significant increase of specificity and lowering of the method limit of detection of the higher molecular weight nitrosamines. The instrumental LOD for different N-nitrosamines was 1-5pginjection-1. The proposed method was exemplified by analysis of N-nitrosamines and N-nitrosatables in rubber teats according to the British Standard BS EN 12868:1999.

KW - N-nitrosamines

KW - Soft ionization

KW - Supersonic molecular beam

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GC determination of N-nitrosamines by supersonic molecular beam MS equipped with triple quadrupole analyzer, GC/SMB/QQQ/MS

Abstract

Bibliographical note

Keywords

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