Gelation of liposome interior A novel method for drug encapsulation

D. D. Lasic; P. M. Frederik; M. C.A. Stuart; Y. Barenholz; T. J. McIntosh

doi:10.1016/0014-5793(92)80947-F

Gelation of liposome interior A novel method for drug encapsulation

D. D. Lasic^*, P. M. Frederik, M. C.A. Stuart, Y. Barenholz, T. J. McIntosh

^*Corresponding author for this work

Alexander Silberman Institute of Life Sciences

Research output: Contribution to journal › Article › peer-review

266 Scopus citations

Abstract

Liposomes can be loaded with weak acids and bases, which exist in solutions in equilibrium with membrane permeable uncharged form, using various gradients across their membranes. Because in some cases the estimated drug concentration in the loaded liposomes exceeds their aqueous solubility we investigated the physical state of the liposome encapsulated anticancer drug Doxorubicin. X-Ray diffraction, electron microscopy and test tube solubility experiments have shown that upon encapsulation the drug molecules form a gel-like phase.

Original language	English
Pages (from-to)	255-258
Number of pages	4
Journal	FEBS Letters
Volume	312
Issue number	2-3
DOIs	https://doi.org/10.1016/0014-5793(92)80947-F
State	Published - 9 Nov 1992

Keywords

(NH)SO, gradient
Doxorubicin
Drug loading
Gel
Liposome

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0014-5793(92)80947-F

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abstract = "Liposomes can be loaded with weak acids and bases, which exist in solutions in equilibrium with membrane permeable uncharged form, using various gradients across their membranes. Because in some cases the estimated drug concentration in the loaded liposomes exceeds their aqueous solubility we investigated the physical state of the liposome encapsulated anticancer drug Doxorubicin. X-Ray diffraction, electron microscopy and test tube solubility experiments have shown that upon encapsulation the drug molecules form a gel-like phase.",

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AU - Lasic, D. D.

AU - Frederik, P. M.

AU - Stuart, M. C.A.

AU - Barenholz, Y.

AU - McIntosh, T. J.

PY - 1992/11/9

Y1 - 1992/11/9

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AB - Liposomes can be loaded with weak acids and bases, which exist in solutions in equilibrium with membrane permeable uncharged form, using various gradients across their membranes. Because in some cases the estimated drug concentration in the loaded liposomes exceeds their aqueous solubility we investigated the physical state of the liposome encapsulated anticancer drug Doxorubicin. X-Ray diffraction, electron microscopy and test tube solubility experiments have shown that upon encapsulation the drug molecules form a gel-like phase.

KW - (NH)SO, gradient

KW - Doxorubicin

KW - Drug loading

KW - Gel

KW - Liposome

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ER -

Gelation of liposome interior A novel method for drug encapsulation

Abstract

Keywords

UN SDGs

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