Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression

Yunus Annayev, Sheera Adar, Yi Ying Chiou, Jason D. Lieb, Aziz Sancar, Rui Ye*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Background: Circadian gene expression in mammals is driven by rhythmic CLOCK-BMAL1 activities. Results: Gm129 binds to the CLOCK-BMAL1 complex on DNA and represses its transcriptional activator activity to regulate the circadian gene expression phase. Conclusion: Gm129 is a novel circadian clock modulator. Significance: The discovery of Gm129 reveals a new regulatory component of circadian gene expression.

Original languageAmerican English
Pages (from-to)5013-5024
Number of pages12
JournalJournal of Biological Chemistry
Volume289
Issue number8
DOIs
StatePublished - 21 Feb 2014

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