Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression

Yunus Annayev; Sheera Adar; Yi Ying Chiou; Jason D. Lieb; Aziz Sancar; Rui Ye

doi:10.1074/jbc.M113.534651

Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression

Yunus Annayev, Sheera Adar, Yi Ying Chiou, Jason D. Lieb, Aziz Sancar, Rui Ye^*

^*Corresponding author for this work

Department of Microbiology and Molecular Genetics

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Background: Circadian gene expression in mammals is driven by rhythmic CLOCK-BMAL1 activities. Results: Gm129 binds to the CLOCK-BMAL1 complex on DNA and represses its transcriptional activator activity to regulate the circadian gene expression phase. Conclusion: Gm129 is a novel circadian clock modulator. Significance: The discovery of Gm129 reveals a new regulatory component of circadian gene expression.

Original language	English
Pages (from-to)	5013-5024
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	289
Issue number	8
DOIs	https://doi.org/10.1074/jbc.M113.534651
State	Published - 21 Feb 2014

Access to Document

10.1074/jbc.M113.534651

Cite this

@article{9afb79d1645d422a8dbc6857b1e09181,

title = "Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression",

abstract = "Background: Circadian gene expression in mammals is driven by rhythmic CLOCK-BMAL1 activities. Results: Gm129 binds to the CLOCK-BMAL1 complex on DNA and represses its transcriptional activator activity to regulate the circadian gene expression phase. Conclusion: Gm129 is a novel circadian clock modulator. Significance: The discovery of Gm129 reveals a new regulatory component of circadian gene expression.",

author = "Yunus Annayev and Sheera Adar and Chiou, {Yi Ying} and Lieb, {Jason D.} and Aziz Sancar and Rui Ye",

year = "2014",

month = feb,

day = "21",

doi = "10.1074/jbc.M113.534651",

language = "אנגלית",

volume = "289",

pages = "5013--5024",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "8",

}

TY - JOUR

T1 - Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression

AU - Annayev, Yunus

AU - Adar, Sheera

AU - Chiou, Yi Ying

AU - Lieb, Jason D.

AU - Sancar, Aziz

AU - Ye, Rui

PY - 2014/2/21

Y1 - 2014/2/21

N2 - Background: Circadian gene expression in mammals is driven by rhythmic CLOCK-BMAL1 activities. Results: Gm129 binds to the CLOCK-BMAL1 complex on DNA and represses its transcriptional activator activity to regulate the circadian gene expression phase. Conclusion: Gm129 is a novel circadian clock modulator. Significance: The discovery of Gm129 reveals a new regulatory component of circadian gene expression.

AB - Background: Circadian gene expression in mammals is driven by rhythmic CLOCK-BMAL1 activities. Results: Gm129 binds to the CLOCK-BMAL1 complex on DNA and represses its transcriptional activator activity to regulate the circadian gene expression phase. Conclusion: Gm129 is a novel circadian clock modulator. Significance: The discovery of Gm129 reveals a new regulatory component of circadian gene expression.

UR - http://www.scopus.com/inward/record.url?scp=84896736467&partnerID=8YFLogxK

U2 - 10.1074/jbc.M113.534651

DO - 10.1074/jbc.M113.534651

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 24385426

AN - SCOPUS:84896736467

SN - 0021-9258

VL - 289

SP - 5013

EP - 5024

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 8

ER -

Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression

Abstract

Access to Document

Other files and links

Fingerprint

Cite this