Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression

Yunus Annayev; Sheera Adar; Yi Ying Chiou; Jason D. Lieb; Aziz Sancar; Rui Ye

doi:10.1074/jbc.M113.534651

Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression

Yunus Annayev
, Sheera Adar
, Yi Ying Chiou
, Jason D. Lieb
, Aziz Sancar
, Rui Ye^*

^*Corresponding author for this work

Department of Microbiology and Molecular Genetics

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Background: Circadian gene expression in mammals is driven by rhythmic CLOCK-BMAL1 activities. Results: Gm129 binds to the CLOCK-BMAL1 complex on DNA and represses its transcriptional activator activity to regulate the circadian gene expression phase. Conclusion: Gm129 is a novel circadian clock modulator. Significance: The discovery of Gm129 reveals a new regulatory component of circadian gene expression.

Original language	English
Pages (from-to)	5013-5024
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	289
Issue number	8
DOIs	https://doi.org/10.1074/jbc.M113.534651
State	Published - 21 Feb 2014

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abstract = "Background: Circadian gene expression in mammals is driven by rhythmic CLOCK-BMAL1 activities. Results: Gm129 binds to the CLOCK-BMAL1 complex on DNA and represses its transcriptional activator activity to regulate the circadian gene expression phase. Conclusion: Gm129 is a novel circadian clock modulator. Significance: The discovery of Gm129 reveals a new regulatory component of circadian gene expression.",

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AU - Lieb, Jason D.

AU - Sancar, Aziz

AU - Ye, Rui

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AB - Background: Circadian gene expression in mammals is driven by rhythmic CLOCK-BMAL1 activities. Results: Gm129 binds to the CLOCK-BMAL1 complex on DNA and represses its transcriptional activator activity to regulate the circadian gene expression phase. Conclusion: Gm129 is a novel circadian clock modulator. Significance: The discovery of Gm129 reveals a new regulatory component of circadian gene expression.

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Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression

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