Abstract
One anastomosis gastric bypass (OAGB) surgery became a common bariatric procedure in recent years. In this surgery, the distal stomach, duodenum, and proximal jejunum are bypassed, leading to weight loss, improvement in metabolic parameters, and a change in hormonal secretion. We sought to generate and characterize a mouse model for OAGB. Mice fed for 26 wk on a high-fat diet were assigned to OAGB, sham surgery, or caloric restriction and were followed for 50 more days on a high-fat diet. Physiological and histological parameters of the mice were compared during and at the end of the experiment. OAGB-operated mice lost weight and displayed low levels of plasma lipids, high insulin sensitivity, and rapid glucose metabolism compared with sham-operated mice. OAGB-operated mice had higher energy expenditure, higher levels of glucagon-like peptide (GLP-1), and lower albumin than weight-matched calorie-restricted mice. There was no difference in the histology of the endocrine pancreas. The livers of OAGB mice had little hepatic steatosis yet presented with a large number of phagocytic cells. The OAGB mouse model recapitulates many of the phenotypes described in patients that underwent OAGB and enables molecular and physiological studies on the outcome of this surgery. NEW & NOTEWORTHY A mouse model for one anastomosis gastric bypass (OAGB) surgery displays similar outcomes to clinical reports and enables to study the weight loss-dependent and -independent effects of this bariatric surgery.
Original language | American English |
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Pages (from-to) | E414-E424 |
Journal | American Journal of Physiology - Endocrinology and Metabolism |
Volume | 322 |
Issue number | 5 |
DOIs | |
State | Published - May 2022 |
Bibliographical note
Funding Information:This study was funded by an European Research Council (ERC) StG Grant 803526 and an Israel Science Foundation (ISF) Research Grant 967/18 (to D.B.-Z.) and an ISF Research Grant 158/ 18 (to J.T.).
Publisher Copyright:
Copyright © 2022 the American Physiological Society.
Keywords
- bariatric surgery
- mouse model
- obesity
- Humans
- Insulin Resistance
- Obesity, Morbid/metabolism
- Animals
- Gastric Bypass/methods
- Bariatric Surgery/methods
- Mice
- Retrospective Studies
- Weight Loss/physiology
- Disease Models, Animal