Genetic analysis of the cIII gene of bacteriophage HK022

D. Kornitzer*, S. Altuvia, A. B. Oppenheim

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


The cIII gene product of lambdoid bacteriophages promotes lysogeny by stabilizing the phage-encoded CII protein, a transcriptional activator of the repressor and integrase genes. Previous works showed that the synthesis of the bacteriophage λ CIII protein has specific translational requirements imposed hy the structure of the mRNA. To gain insight into the mRNA structure and its role in regulating cIII translation, we undertook a mutational analysis of the cIII gene of the related bacteriophage HK022. Our data support the hypothesis that in HK022, as in λ, translation initiation requires a specific mRNA structure. In addition, we found that translation of HK022 cIII, like that of λ, is strongly reduced in a host deficient in the endonuclease RNase III.

Original languageAmerican English
Pages (from-to)810-815
Number of pages6
JournalJournal of Bacteriology
Issue number2
StatePublished - 1991


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