Genetic and antigenic relatedness between Mycoplasma gallisepticum and Mycoplasma synoviae

D. Yogev*, S. Levisohn, S. Razin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


The two avian pathogens Mycoplasma gallisepticum and Mycoplasma synoviae were found, by Southern blot hybridization of their digested DNAs, to share genomic nucleotide sequences additional to those of the highly conserved ribosomal RNA genes. The assumption that some of the shared sequences encode for antigens or epitopes common to both mycoplasmas was supported by Western immunoblot analysis of cell proteins of one mycoplasma with specific antiserum to the other mycoplasma. Interestingly, the band patterns of reactive antigens were different for some of the M. gallisepticum strains, supporting the concept that the species is genotypically variable. The results of the present study may explain the cross-reactivity of the two mycoplasmas noted previously in a variety of routine serological tests.

Original languageAmerican English
Pages (from-to)75-84
Number of pages10
JournalVeterinary Microbiology
Issue number1
StatePublished - Jan 1989

Bibliographical note

Funding Information:
This study was supported by a grant (No. 1-939-85 ) from the United States-Israel Binational Agricultural Research and Development Fund (BARD). We


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