Genetic control of resistance to trypanosomiasis

S. J. Kemp*, A. Darvasi, M. Soller, A. J. Teale

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

To map the genetic sources of trypanotolerance in mice, a linkage analysis of survival following trypanosome challenge was performed by selective genotyping in a large F2 population produced by crossing the resistant C57BL/6 and susceptible BALB/c inbred mouse lines. We report evidence of a chromosomal region of large effect, possibly comprising more than one resistance locus, on Chromosome 17; and of further loci on Chromosomes 1 and 5. Together, these genes can account for all of the difference between the mean parental phenotypes.

Original languageEnglish
Pages (from-to)239-243
Number of pages5
JournalVeterinary Immunology and Immunopathology
Volume54
Issue number1-4
DOIs
StatePublished - Nov 1996

Keywords

  • genetic control
  • resistance
  • trypanosomiasis

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