Abstract
To map the genetic sources of trypanotolerance in mice, a linkage analysis of survival following trypanosome challenge was performed by selective genotyping in a large F2 population produced by crossing the resistant C57BL/6 and susceptible BALB/c inbred mouse lines. We report evidence of a chromosomal region of large effect, possibly comprising more than one resistance locus, on Chromosome 17; and of further loci on Chromosomes 1 and 5. Together, these genes can account for all of the difference between the mean parental phenotypes.
Original language | English |
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Pages (from-to) | 239-243 |
Number of pages | 5 |
Journal | Veterinary Immunology and Immunopathology |
Volume | 54 |
Issue number | 1-4 |
DOIs | |
State | Published - Nov 1996 |
Keywords
- genetic control
- resistance
- trypanosomiasis