Genetic dissection of common diseases

Naomi B. Zak*, Sagiv Shifman, Anne Shalom, Ariel Darvasi

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


The complex genetic nature of many common diseases makes the identification of the genes that predispose to these ailments a difficult task. In this review we discuss the elements that contribute to the complexity of polygenic diseases and describe an experimental strategy for disease-related gene discovery that attempts to overcome these factors. This strategy involves a population-based case-control paradigm and makes use of a highly informative, homogeneous founder population, many of whose members presently reside in Israel. The properties of single nucleotide polymorphisms, which are presently the markers of choice, are discussed, and the technologies that are currently available for SNP genotyping are briefly presented.

Original languageAmerican English
Pages (from-to)438-443
Number of pages6
JournalIsrael Medical Association Journal
Issue number6
StatePublished - 2002
Externally publishedYes


  • Association studies
  • Case/control
  • Complex genetic diseases
  • Homogenous populations
  • Single nucleotide polymorphisms


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