Abstract
Drosophila phototransduction utilizes the phosphoinositide signaling cascade. It is characterized by phospholipase C as the effector enzyme and the Transient Receptor Potential (TRP) channels as its target. This cascade has been extensively studied in Drosophila because of its powerful molecular genetic tools and the unparalleled large number of mutants produced. These mutants have led to the discovery of novel proteins and processes that otherwise would have been difficult to predict. Currently, Drosophila photoreceptors are one of the few systems in which phosphoinositide signaling and TRP channels can be studied in vivo; thus making Drosophila phototransduction a highly valuable model system.
| Original language | English |
|---|---|
| Title of host publication | The Curated Reference Collection in Neuroscience and Biobehavioral Psychology |
| Publisher | Elsevier Science Ltd. |
| Pages | 195-206 |
| Number of pages | 12 |
| ISBN (Electronic) | 9780128093245 |
| DOIs | |
| State | Published - 1 Jan 2016 |
Bibliographical note
Publisher Copyright:© 2017 Elsevier Inc. All rights reserved.
Keywords
- Drosophila mutants
- Drosophila phototransduction
- G-protein
- INAD signaling complex
- Inositol-lipid signaling
- Phospholipase C
- Poly unsaturated fatty acids
- Prolonged depolarizing afterpotential
- Rhodopsin
- Single photon responses
- TRP channels