Abstract
Drosophila phototransduction utilizes the phosphoinositide signaling cascade for visual processing. It is characterized by phospholipase C as the effector enzyme and the transient receptor potential (TRP) channels as its target. This cascade has been extensively studied in Drosophila because of its powerful molecular genetic tools and the unparalleled large number of mutants produced. These mutants have led to the discovery of novel proteins and processes that, otherwise, would have been difficult to predict. Currently, Drosophila photoreceptors are one of the few systems in which phosphoinositide signaling and TRP channels can be studied in vivo, thus making Drosophila phototransduction a highly valuable model system.
| Original language | English |
|---|---|
| Title of host publication | Encyclopedia of the Eye |
| Publisher | Elsevier |
| Pages | 195-206 |
| Number of pages | 12 |
| ISBN (Electronic) | 9780123742032 |
| ISBN (Print) | 9780123741981 |
| DOIs | |
| State | Published - 1 Jan 2010 |
Bibliographical note
Publisher Copyright:© 2010 Elsevier Ltd. All rights reserved.
Keywords
- Drosophila mutants
- Drosophila phototransduction
- G-protein
- INAD signaling complex
- Inositol-lipid signaling
- Phospholipase C
- Polyunsaturated fatty acids
- Prolonged depolarizing after potential
- Rhodopsin
- Single photon responses
- TRP channels