Genetic Dissection of the Oncogenic mTOR Pathway Reveals Druggable Addiction to Translational Control via 4EBP-eIF4E

Keyphrases

• 4E-BP1 100%
• Active Site Inhibitors 20%
• Addiction 100%
• Anti-apoptotic Proteins 20%
• Cancer Formation 20%
• Cancer Initiation 20%
• Cancer Progression 20%
• Cap-dependent Translation 20%
• Cell Growth 20%
• Drug-resistant Tumor 20%
• Druggability 100%
• Eukaryotic Translation Initiation Factor 4E (eIF4E) 100%
• Genetic Dissection 100%
• Human Cancer 20%
• Hyperactivity 20%
• Lymphomagenesis 20%
• Mammalian Target of Rapamycin (mTOR) 80%
• MTOR Pathway 100%
• Myeloid Cell leukemia-1 (Mcl-1) 20%
• Phosphorylation 20%
• PP242 40%
• Rapamycin 20%
• RPS6 20%
• Therapeutic Benefits 20%
• Therapeutic Response 20%
• Translational Control 100%
• Tumorigenesis 20%

Medicine and Dentistry

• 2 (4 Amino 1 Isopropyl 1h pyrazolo[3,4 D]pyrimidin 3 Yl) 1h Indol 5 Ol 50%
• Addictive Behavior 100%
• Antiapoptotic 25%
• Cancer 25%
• Cancer Growth 25%
• Carcinogenesis 100%
• Hyperactivation 25%
• Initiation Factor 4E 100%
• Malignant Neoplasm 25%
• Mammalian Target of Rapamycin 100%
• Mediator 25%
• mTOR Signaling 25%
• Protein Kinase B 50%
• Rapamycin 25%
• Treatment Response 25%
• Tumor 25%

Biochemistry, Genetics and Molecular Biology

• Active Site 33%
• Carcinogenesis 100%
• Cell Growth 33%
• Genetics 100%
• Mammalian Target of Rapamycin 100%
• Mediator 33%
• mTOR Signaling 33%
• Protein Kinase B 66%