Genetic distances separating adjacent base pairs in bacteriophage T4

A. Ronen; Y. Salts

doi:10.1016/0042-6822(71)90349-7

Genetic distances separating adjacent base pairs in bacteriophage T4

A. Ronen^*, Y. Salts

^*Corresponding author for this work

Alexander Silberman Institute of Life Sciences

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

In 12 sites within the rII region, homologous UAG (amber) and UGA (opal) mutants were isolated. Recombination between each pair of nonsense mutants, leading to a wild-type genotype, was studied. Such experiments measure recombination between adjacent nucleotides. Frequencies varied from 6.2 × 10^-7 to under 2 × 10^-10. Even the higher frequency is more than two orders of magnitude below the predictions obtained from experiments measuring average genetic distances.

Original language	English
Pages (from-to)	496-502
Number of pages	7
Journal	Virology
Volume	45
Issue number	2
DOIs	https://doi.org/10.1016/0042-6822(71)90349-7
State	Published - Aug 1971

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title = "Genetic distances separating adjacent base pairs in bacteriophage T4",

abstract = "In 12 sites within the rII region, homologous UAG (amber) and UGA (opal) mutants were isolated. Recombination between each pair of nonsense mutants, leading to a wild-type genotype, was studied. Such experiments measure recombination between adjacent nucleotides. Frequencies varied from 6.2 × 10-7 to under 2 × 10-10. Even the higher frequency is more than two orders of magnitude below the predictions obtained from experiments measuring average genetic distances.",

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AB - In 12 sites within the rII region, homologous UAG (amber) and UGA (opal) mutants were isolated. Recombination between each pair of nonsense mutants, leading to a wild-type genotype, was studied. Such experiments measure recombination between adjacent nucleotides. Frequencies varied from 6.2 × 10-7 to under 2 × 10-10. Even the higher frequency is more than two orders of magnitude below the predictions obtained from experiments measuring average genetic distances.

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Genetic distances separating adjacent base pairs in bacteriophage T4

Abstract

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