Genetic factors conferring metastasis in osteosarcoma

Vadim V. Maximov*, Rami I. Aqeilan

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations

Abstract

Osteosarcoma (OS) is a deadly bone malignancy affecting mostly children and adolescents. OS has outstandingly complex genetic alterations likely due to p53-independent genomic instability. Based on analysis of recent published research we claim existence of various genetic mechanisms of osteosarcomagenesis conferring great variability to different OS properties including metastatic potential. We also propose a model explaining how diverse genetic mechanisms occur and providing a framework for future research. P53-independent preexisting genomic instability, which precedes and frequently causes TP53 genetic alterations, is central in our model. In addition, our analyses reveal a possible cooperation between aberrantly activated HIF-1α and AP-1 genetic pathways in OS metastasis. We also review the involvement of noncoding RNA genes in OS metastasis.

Original languageAmerican English
Pages (from-to)1623-1644
Number of pages22
JournalFuture Oncology
Volume12
Issue number13
DOIs
StatePublished - Jul 2016

Bibliographical note

Publisher Copyright:
© 2016 Future Medicine Ltd.

Keywords

  • genomic instability
  • metastasis
  • osteosarcoma
  • p53
  • pathway

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