Genetic influences on brain stimulation-produced analgesia in mice: II. Correlation with brain opiate receptor concentration

Przemyslaw Marek, Raz Yirmiya, John C. Liebeskind*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

The analgesic effect of electrical stimulation of the periaqueductal gray matter (PAG) was studied in 4 strains of mice: C57BL/6By (C57), BALB/cBy (BALB), CXBH, and CXBK. These strains are known to have high (CXBH), low (CXBK), and intermediate (C57 and BALB) concentrations of brain opiate receptors. The current intensity required for stimulation-produced analgesia (SPA) did not differ among strains. Naloxone attenuated SPA in CXBH, C57 and BALB mice, but was ineffective in the opiate receptor deficient CXBK mice. The results suggest that genetic differences in opiate receptor density can influence the degree to which opioid mechanisms are involved in SPA from the PAG.

Original languageAmerican English
Pages (from-to)155-157
Number of pages3
JournalBrain Research
Volume507
Issue number1
DOIs
StatePublished - 15 Jan 1990
Externally publishedYes

Bibliographical note

Funding Information:
Supported by NIH Grant NS07628 and an Unrestricted Pare Research Grant from the Bristol-Myers Company

Keywords

  • Genetic difference
  • Naloxone
  • Opiate receptor
  • Periaqueductal gray matter
  • Stimulation-produced analgesia

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