Genetic influences on brain stimulation-produced analgesia in mice: II. Correlation with brain opiate receptor concentration

Przemyslaw Marek; Raz Yirmiya; John C. Liebeskind

doi:10.1016/0006-8993(90)90536-K

Genetic influences on brain stimulation-produced analgesia in mice: II. Correlation with brain opiate receptor concentration

Przemyslaw Marek, Raz Yirmiya, John C. Liebeskind^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The analgesic effect of electrical stimulation of the periaqueductal gray matter (PAG) was studied in 4 strains of mice: C57BL/6By (C57), BALB/cBy (BALB), CXBH, and CXBK. These strains are known to have high (CXBH), low (CXBK), and intermediate (C57 and BALB) concentrations of brain opiate receptors. The current intensity required for stimulation-produced analgesia (SPA) did not differ among strains. Naloxone attenuated SPA in CXBH, C57 and BALB mice, but was ineffective in the opiate receptor deficient CXBK mice. The results suggest that genetic differences in opiate receptor density can influence the degree to which opioid mechanisms are involved in SPA from the PAG.

Original language	English
Pages (from-to)	155-157
Number of pages	3
Journal	Brain Research
Volume	507
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(90)90536-K
State	Published - 15 Jan 1990
Externally published	Yes

Bibliographical note

Funding Information:
Supported by NIH Grant NS07628 and an Unrestricted Pare Research Grant from the Bristol-Myers Company

Keywords

Genetic difference
Naloxone
Opiate receptor
Periaqueductal gray matter
Stimulation-produced analgesia

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10.1016/0006-8993(90)90536-K

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title = "Genetic influences on brain stimulation-produced analgesia in mice: II. Correlation with brain opiate receptor concentration",

abstract = "The analgesic effect of electrical stimulation of the periaqueductal gray matter (PAG) was studied in 4 strains of mice: C57BL/6By (C57), BALB/cBy (BALB), CXBH, and CXBK. These strains are known to have high (CXBH), low (CXBK), and intermediate (C57 and BALB) concentrations of brain opiate receptors. The current intensity required for stimulation-produced analgesia (SPA) did not differ among strains. Naloxone attenuated SPA in CXBH, C57 and BALB mice, but was ineffective in the opiate receptor deficient CXBK mice. The results suggest that genetic differences in opiate receptor density can influence the degree to which opioid mechanisms are involved in SPA from the PAG.",

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author = "Przemyslaw Marek and Raz Yirmiya and Liebeskind, {John C.}",

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AU - Yirmiya, Raz

AU - Liebeskind, John C.

N1 - Funding Information: Supported by NIH Grant NS07628 and an Unrestricted Pare Research Grant from the Bristol-Myers Company

PY - 1990/1/15

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AB - The analgesic effect of electrical stimulation of the periaqueductal gray matter (PAG) was studied in 4 strains of mice: C57BL/6By (C57), BALB/cBy (BALB), CXBH, and CXBK. These strains are known to have high (CXBH), low (CXBK), and intermediate (C57 and BALB) concentrations of brain opiate receptors. The current intensity required for stimulation-produced analgesia (SPA) did not differ among strains. Naloxone attenuated SPA in CXBH, C57 and BALB mice, but was ineffective in the opiate receptor deficient CXBK mice. The results suggest that genetic differences in opiate receptor density can influence the degree to which opioid mechanisms are involved in SPA from the PAG.

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KW - Naloxone

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Genetic influences on brain stimulation-produced analgesia in mice: II. Correlation with brain opiate receptor concentration

Abstract

Bibliographical note

Keywords

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