Genetic influences on brain stimulation-produced analgesia in mice. I. Correlation with stress-induced analgesia

Przemyslaw Marek; Raz Yirmiya; Izabela Panocka; John C. Liebeskind

doi:10.1016/0006-8993(89)90022-X

Genetic influences on brain stimulation-produced analgesia in mice. I. Correlation with stress-induced analgesia

Przemyslaw Marek^*, Raz Yirmiya, Izabela Panocka, John C. Liebeskind

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The analgesic effect of electrical stimulation of the periaqueductal gray matter (PAG) was studied in mice selectively bred for high and low stress-induced analgesia (HA and LA lines, respectively). The current intensity required for stimulation-produced analgesia (SPA) in LA mice was 5 times that for HA mice. Naloxone produced a 4-fold increase of SPA threshold in HA mice, but was ineffective in LA mice. These findings suggest that the differential responsiveness of these two lines to the analgesic effect of stress reflects a more general genetic modification of the efficacy and mechanism of their pain-inhibitory systems.

Original language	English
Pages (from-to)	182-184
Number of pages	3
Journal	Brain Research
Volume	489
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(89)90022-X
State	Published - 5 Jun 1989
Externally published	Yes

Bibliographical note

Funding Information:
Supported by NIH Grant NS07628 and the Polish Academy of Sciences Project CPBP-04.01/6.13.

Keywords

Genetic difference
Naloxone
Periaqueductal gray matter
Stimulation-produced analgesia
Swim-induced analgesia

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10.1016/0006-8993(89)90022-X

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abstract = "The analgesic effect of electrical stimulation of the periaqueductal gray matter (PAG) was studied in mice selectively bred for high and low stress-induced analgesia (HA and LA lines, respectively). The current intensity required for stimulation-produced analgesia (SPA) in LA mice was 5 times that for HA mice. Naloxone produced a 4-fold increase of SPA threshold in HA mice, but was ineffective in LA mice. These findings suggest that the differential responsiveness of these two lines to the analgesic effect of stress reflects a more general genetic modification of the efficacy and mechanism of their pain-inhibitory systems.",

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AU - Yirmiya, Raz

AU - Panocka, Izabela

AU - Liebeskind, John C.

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Genetic influences on brain stimulation-produced analgesia in mice. I. Correlation with stress-induced analgesia

Abstract

Bibliographical note

Keywords

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