TY - JOUR
T1 - Genetic toggle switch without cooperative binding
AU - Lipshtat, Azi
AU - Loinger, Adiel
AU - Balaban, Nathalie Q.
AU - Biham, Ofer
PY - 2006
Y1 - 2006
N2 - Genetic switch systems with mutual repression of two transcription factors are studied using deterministic and stochastic methods. Numerous studies have concluded that cooperative binding is a necessary condition for the emergence of bistability in these systems. Here we show that, for a range of biologically relevant conditions, a suitable combination of network structure and stochastic effects gives rise to bistability even without cooperative binding.
AB - Genetic switch systems with mutual repression of two transcription factors are studied using deterministic and stochastic methods. Numerous studies have concluded that cooperative binding is a necessary condition for the emergence of bistability in these systems. Here we show that, for a range of biologically relevant conditions, a suitable combination of network structure and stochastic effects gives rise to bistability even without cooperative binding.
UR - http://www.scopus.com/inward/record.url?scp=33646397850&partnerID=8YFLogxK
U2 - 10.1103/PhysRevLett.96.188101
DO - 10.1103/PhysRevLett.96.188101
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
AN - SCOPUS:33646397850
SN - 0031-9007
VL - 96
JO - Physical Review Letters
JF - Physical Review Letters
IS - 18
M1 - 188101
ER -