Genetic toggle switch without cooperative binding

Azi Lipshtat*, Adiel Loinger, Nathalie Q. Balaban, Ofer Biham

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

153 Scopus citations

Abstract

Genetic switch systems with mutual repression of two transcription factors are studied using deterministic and stochastic methods. Numerous studies have concluded that cooperative binding is a necessary condition for the emergence of bistability in these systems. Here we show that, for a range of biologically relevant conditions, a suitable combination of network structure and stochastic effects gives rise to bistability even without cooperative binding.

Original languageAmerican English
Article number188101
JournalPhysical Review Letters
Volume96
Issue number18
DOIs
StatePublished - 2006

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