Abstract
Genetic switch systems with mutual repression of two transcription factors are studied using deterministic and stochastic methods. Numerous studies have concluded that cooperative binding is a necessary condition for the emergence of bistability in these systems. Here we show that, for a range of biologically relevant conditions, a suitable combination of network structure and stochastic effects gives rise to bistability even without cooperative binding.
Original language | American English |
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Article number | 188101 |
Journal | Physical Review Letters |
Volume | 96 |
Issue number | 18 |
DOIs | |
State | Published - 2006 |