Genetic variation of three tetrameric tandem repeats in four distinct Israeli ethnic groups

Avraham Amar; Chaim Brautbar; Uzi Motro; Tovi Fisher; Batsheva Bonne-Tamir; Shoshana Israel

doi:10.1520/jfs12027j

Genetic variation of three tetrameric tandem repeats in four distinct Israeli ethnic groups

Avraham Amar^*, Chaim Brautbar, Uzi Motro, Tovi Fisher, Batsheva Bonne-Tamir, Shoshana Israel

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The allele frequency distributions of three STR loci amplified by PCR have been studied in four Israeli communities: Ashkenazi Jews and three non- Ashkenazi groups, namely Moroccan, Yemenite, and Ethiopian Jews. The loci analyzed were CSF1PO, TPOX, and HUMTHO1. The typing was performed in sequencing polyacrylamide gels under denaturing conditions that could separate alleles with differences of a single base. The population data were analyzed with respect to Hardy-Weinberg (H-W) equilibrium and found that all loci meet the H-W expectations. Noticeable differences were encountered between the four Jewish ethnic groups studied hereby indicating the importance of establishing a local database to be used in human identity testing in these different Israeli Jewish groups.

Original language	English
Pages (from-to)	983-986
Number of pages	4
Journal	Journal of Forensic Sciences
Volume	44
Issue number	5
DOIs	https://doi.org/10.1520/jfs12027j
State	Published - Sep 1999

Keywords

Allele frequencies
CSF1PO
Database
DNA typing
Ethnic groups
Forensic science
Israel
Population genetics
Short tandem repeats
THO1
TPOX

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10.1520/jfs12027j

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title = "Genetic variation of three tetrameric tandem repeats in four distinct Israeli ethnic groups",

abstract = "The allele frequency distributions of three STR loci amplified by PCR have been studied in four Israeli communities: Ashkenazi Jews and three non- Ashkenazi groups, namely Moroccan, Yemenite, and Ethiopian Jews. The loci analyzed were CSF1PO, TPOX, and HUMTHO1. The typing was performed in sequencing polyacrylamide gels under denaturing conditions that could separate alleles with differences of a single base. The population data were analyzed with respect to Hardy-Weinberg (H-W) equilibrium and found that all loci meet the H-W expectations. Noticeable differences were encountered between the four Jewish ethnic groups studied hereby indicating the importance of establishing a local database to be used in human identity testing in these different Israeli Jewish groups.",

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AU - Motro, Uzi

AU - Fisher, Tovi

AU - Bonne-Tamir, Batsheva

AU - Israel, Shoshana

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AB - The allele frequency distributions of three STR loci amplified by PCR have been studied in four Israeli communities: Ashkenazi Jews and three non- Ashkenazi groups, namely Moroccan, Yemenite, and Ethiopian Jews. The loci analyzed were CSF1PO, TPOX, and HUMTHO1. The typing was performed in sequencing polyacrylamide gels under denaturing conditions that could separate alleles with differences of a single base. The population data were analyzed with respect to Hardy-Weinberg (H-W) equilibrium and found that all loci meet the H-W expectations. Noticeable differences were encountered between the four Jewish ethnic groups studied hereby indicating the importance of establishing a local database to be used in human identity testing in these different Israeli Jewish groups.

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KW - TPOX

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Genetic variation of three tetrameric tandem repeats in four distinct Israeli ethnic groups

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