TY - JOUR
T1 - Genetically engineered mesenchymal stem cells
T2 - Applications in spine therapy
AU - Aslan, Hadi
AU - Sheyn, Dima
AU - Gazit, Dan
PY - 2009
Y1 - 2009
N2 - Spine disorders and intervertebral disc degeneration are considered the main causes for the clinical condition commonly known as back pain. Spinal fusion by implanting autologous bone to produce bony bridging between the two vertebrae fianking the degenerated-intervertebral disc is currently the most efficient treatment for relieving the symptoms of back pain. However, donor-site morbidity, complications and the long healing time limit the success of this approach. Novel developments undertaken by regenerative medicine might bring more efficient and available treatments. Here we discuss the pros and cons of utilizing genetically engineered mesenchymal stem cells for inducing spinal fusion. The combination of the stem cells, gene and carrier are crucial elements for achieving optimal spinal fusion in both small and large animal models, which hopefully will lead to the development of clinical applications.
AB - Spine disorders and intervertebral disc degeneration are considered the main causes for the clinical condition commonly known as back pain. Spinal fusion by implanting autologous bone to produce bony bridging between the two vertebrae fianking the degenerated-intervertebral disc is currently the most efficient treatment for relieving the symptoms of back pain. However, donor-site morbidity, complications and the long healing time limit the success of this approach. Novel developments undertaken by regenerative medicine might bring more efficient and available treatments. Here we discuss the pros and cons of utilizing genetically engineered mesenchymal stem cells for inducing spinal fusion. The combination of the stem cells, gene and carrier are crucial elements for achieving optimal spinal fusion in both small and large animal models, which hopefully will lead to the development of clinical applications.
KW - Back pain
KW - Bone morphogenetic proteins
KW - Gene therapy
KW - Intervertebral disc
KW - Mesenchymal stem cells
KW - Spinal fusion
UR - http://www.scopus.com/inward/record.url?scp=58949095034&partnerID=8YFLogxK
U2 - 10.2217/17460751.4.1.99
DO - 10.2217/17460751.4.1.99
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???
C2 - 19105619
AN - SCOPUS:58949095034
SN - 1746-0751
VL - 4
SP - 99
EP - 108
JO - Regenerative Medicine
JF - Regenerative Medicine
IS - 1
ER -