Genetics of crohn’s disease: No link with the pseudoautosomal region of the x chromosome

Objective: In view of the high prevalence of Crohn's disease among women with Turner’s syndrome, we searched for a putative Crohn’s disease locus on the X chromosome, which is deleted in Turner’s syndrome. Subjects and methods:Because Crohn’s disease is equally prevalent in men and women, the search was focused on the pseudoautosomal region of the X chromosome. Blood samples from two families with healthy siblings and siblings with Crohn’s disease were analysed by restriction fragment length polymorphism. The probes used in the analysis were derived from the pseudoautosomal region of the X chromosome. Results:No link was found between Crohn’s disease and the pseudoautosomal region of the X chromosome. Conclusion:The putative Crohn’s disease locus is not located in the pseudoautosomal region of the X chromosome.