Genome maintenance in pluripotent stem cells

Uri Weissbein, Nissim Benvenisty*, Uri Ben-David

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

111 Scopus citations

Abstract

Pluripotent stem cells (PSCs) must maintain their proper genomic content in order to preserve appropriate selfrenewal and differentiation capacities. However, their prolonged in vitro propagation, as well as the environmental culture conditions, present serious challenges to genome maintenance. Recent work has been focused on potential means to alleviate the genomic insults experienced by PSCs, and to detect them as soon as they arise, in order to prevent the detrimental consequences of these genomic aberrations on PSC application in basic research and regenerative medicine.

Original languageAmerican English
Pages (from-to)153-163
Number of pages11
JournalJournal of Cell Biology
Volume204
Issue number2
DOIs
StatePublished - 20 Jan 2014

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