TY - JOUR
T1 - Genome maintenance in pluripotent stem cells
AU - Weissbein, Uri
AU - Benvenisty, Nissim
AU - Ben-David, Uri
PY - 2014/1/20
Y1 - 2014/1/20
N2 - Pluripotent stem cells (PSCs) must maintain their proper genomic content in order to preserve appropriate selfrenewal and differentiation capacities. However, their prolonged in vitro propagation, as well as the environmental culture conditions, present serious challenges to genome maintenance. Recent work has been focused on potential means to alleviate the genomic insults experienced by PSCs, and to detect them as soon as they arise, in order to prevent the detrimental consequences of these genomic aberrations on PSC application in basic research and regenerative medicine.
AB - Pluripotent stem cells (PSCs) must maintain their proper genomic content in order to preserve appropriate selfrenewal and differentiation capacities. However, their prolonged in vitro propagation, as well as the environmental culture conditions, present serious challenges to genome maintenance. Recent work has been focused on potential means to alleviate the genomic insults experienced by PSCs, and to detect them as soon as they arise, in order to prevent the detrimental consequences of these genomic aberrations on PSC application in basic research and regenerative medicine.
UR - http://www.scopus.com/inward/record.url?scp=84892878347&partnerID=8YFLogxK
U2 - 10.1083/jcb.201310135
DO - 10.1083/jcb.201310135
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C2 - 24446481
AN - SCOPUS:84892878347
SN - 0021-9525
VL - 204
SP - 153
EP - 163
JO - Journal of Cell Biology
JF - Journal of Cell Biology
IS - 2
ER -