Genome-wide analysis of the replication program in mammals

Shlomit Farkash-Amar, Itamar Simon*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

49 Scopus citations

Abstract

Microarray technology has facilitated the research of eukaryotic DNA replication on a genome-wide scale. Recent studies have shed light on the association between time of replication and chromosome structure, on the organization principles of the replication program, and on the correlation between replication timing and transcription. In this review, we summarize various genomic measurement approaches and the biological insights achieved through applying them in the study of the mammalian replication program.

Original languageAmerican English
Pages (from-to)115-125
Number of pages11
JournalChromosome Research
Volume18
Issue number1
DOIs
StatePublished - Jan 2010

Keywords

  • Epigenetic
  • Genomic stability
  • Genomics
  • Microarrays
  • Time of replication
  • Transcription

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