TY - JOUR
T1 - Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder
AU - Lasky-Su, Jessica
AU - Anney, Richard J.L.
AU - Neale, Benjamin M.
AU - Franke, Barbara
AU - Zhou, Kaixin
AU - Maller, Julian B.
AU - Vasquez, Alejandro Arias
AU - Chen, Wai
AU - Asherson, Philip
AU - Buitelaar, Jan
AU - Banaschewski, Tobias
AU - Ebstein, Richard
AU - Gill, Michael
AU - Miranda, Ana
AU - Mulas, Fernando
AU - Oades, Robert D.
AU - Roeyers, Herbert
AU - Rothenberger, Aribert
AU - Sergeant, Joseph
AU - Sonuga-Barke, Edmund
AU - Steinhausen, Hans Christoph
AU - Taylor, Eric
AU - Daly, Mark
AU - Laird, Nan
AU - Lange, Christoph
AU - Faraone, Stephen V.
PY - 2008/12/5
Y1 - 2008/12/5
N2 - A time-to-onset analysis for family-based samples was performed on the genomewide association (GWAS) data for attention deficit hyperactivity disorder (ADHD) to determine if associations exist with the age at onset of ADHD. The initial dataset consisted of 958 parent-offspring trios that were genotyped on the Perlegen 600,000 SNP array. After data cleaning procedures, 429,981 autosomal SNPs and 930 parent-offspring trios were used found suitable for use and a family-based logrank analysis was performed using that age at first ADHD symptoms as the quantitative trait of interest. No SNP achieved genome-wide significance, and the lowest P-values had a magnitude of 10-7. Several SNPs amonga pre-specified list of candidate genes had nominal associations including SLC9A9, DRD1, ADRB2, SLC6A3, NFIL3, ADRB1, SYT1, HTR2A, ARRB2, and CHRNA4. Of0 these findings SLC9A9 stood out as a promising candidate, with nominally significant SNPs in six distinct regions of the gene.
AB - A time-to-onset analysis for family-based samples was performed on the genomewide association (GWAS) data for attention deficit hyperactivity disorder (ADHD) to determine if associations exist with the age at onset of ADHD. The initial dataset consisted of 958 parent-offspring trios that were genotyped on the Perlegen 600,000 SNP array. After data cleaning procedures, 429,981 autosomal SNPs and 930 parent-offspring trios were used found suitable for use and a family-based logrank analysis was performed using that age at first ADHD symptoms as the quantitative trait of interest. No SNP achieved genome-wide significance, and the lowest P-values had a magnitude of 10-7. Several SNPs amonga pre-specified list of candidate genes had nominal associations including SLC9A9, DRD1, ADRB2, SLC6A3, NFIL3, ADRB1, SYT1, HTR2A, ARRB2, and CHRNA4. Of0 these findings SLC9A9 stood out as a promising candidate, with nominally significant SNPs in six distinct regions of the gene.
KW - ADHD
KW - Genomewide association
KW - PBAT
KW - Time-toonset
UR - https://www.scopus.com/pages/publications/57349161373
U2 - 10.1002/ajmg.b.30869
DO - 10.1002/ajmg.b.30869
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C2 - 18937294
AN - SCOPUS:57349161373
SN - 1552-4841
VL - 147
SP - 1355
EP - 1358
JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
IS - 8
ER -