Genomic dissection reveals locus response to stress for mammalian acetylcholinesterase

Alastair D. Grant, Michael Shapira, Hermona Soreq*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The mammalian acetylcholinesterase (ACHE) locus was investigated using computational predictive methods and experiments of reverse transcription polymerase chain reaction (RT-PCR). Computational analysis identified two genes downstream to ACHE, an inversely oriented arsenite resistance gene homologue (ARS), and a novel previously unidentified gene (PIX), co-oriented with ACHE. Experimental evidence shows coregulation of murine ACHE and ARS following confined swim, indicating coordinated locus response to stress, that is possibly mediated by altered cholinergic neurotransmission.

Original languageEnglish
Pages (from-to)783-797
Number of pages15
JournalCellular and Molecular Neurobiology
Volume21
Issue number6
DOIs
StatePublished - 2001

Keywords

  • Acetylcholinesterase
  • ARS
  • Locus response
  • PIX
  • Stress response

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