TY - JOUR
T1 - Genomic dissection reveals locus response to stress for mammalian acetylcholinesterase
AU - Grant, Alastair D.
AU - Shapira, Michael
AU - Soreq, Hermona
PY - 2001
Y1 - 2001
N2 - The mammalian acetylcholinesterase (ACHE) locus was investigated using computational predictive methods and experiments of reverse transcription polymerase chain reaction (RT-PCR). Computational analysis identified two genes downstream to ACHE, an inversely oriented arsenite resistance gene homologue (ARS), and a novel previously unidentified gene (PIX), co-oriented with ACHE. Experimental evidence shows coregulation of murine ACHE and ARS following confined swim, indicating coordinated locus response to stress, that is possibly mediated by altered cholinergic neurotransmission.
AB - The mammalian acetylcholinesterase (ACHE) locus was investigated using computational predictive methods and experiments of reverse transcription polymerase chain reaction (RT-PCR). Computational analysis identified two genes downstream to ACHE, an inversely oriented arsenite resistance gene homologue (ARS), and a novel previously unidentified gene (PIX), co-oriented with ACHE. Experimental evidence shows coregulation of murine ACHE and ARS following confined swim, indicating coordinated locus response to stress, that is possibly mediated by altered cholinergic neurotransmission.
KW - Acetylcholinesterase
KW - ARS
KW - Locus response
KW - PIX
KW - Stress response
UR - http://www.scopus.com/inward/record.url?scp=0035565002&partnerID=8YFLogxK
U2 - 10.1023/A:1015112407079
DO - 10.1023/A:1015112407079
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C2 - 12043848
AN - SCOPUS:0035565002
SN - 0272-4340
VL - 21
SP - 783
EP - 797
JO - Cellular and Molecular Neurobiology
JF - Cellular and Molecular Neurobiology
IS - 6
ER -