Genomic dissection reveals locus response to stress for mammalian acetylcholinesterase

Alastair D. Grant; Michael Shapira; Hermona Soreq

doi:10.1023/A:1015112407079

Genomic dissection reveals locus response to stress for mammalian acetylcholinesterase

Alastair D. Grant
, Michael Shapira
, Hermona Soreq^*

^*Corresponding author for this work

Alexander Silberman Institute of Life Sciences

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The mammalian acetylcholinesterase (ACHE) locus was investigated using computational predictive methods and experiments of reverse transcription polymerase chain reaction (RT-PCR). Computational analysis identified two genes downstream to ACHE, an inversely oriented arsenite resistance gene homologue (ARS), and a novel previously unidentified gene (PIX), co-oriented with ACHE. Experimental evidence shows coregulation of murine ACHE and ARS following confined swim, indicating coordinated locus response to stress, that is possibly mediated by altered cholinergic neurotransmission.

Original language	English
Pages (from-to)	783-797
Number of pages	15
Journal	Cellular and Molecular Neurobiology
Volume	21
Issue number	6
DOIs	https://doi.org/10.1023/A:1015112407079
State	Published - 2001

Keywords

ARS
Acetylcholinesterase
Locus response
PIX
Stress response

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10.1023/A:1015112407079

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title = "Genomic dissection reveals locus response to stress for mammalian acetylcholinesterase",

abstract = "The mammalian acetylcholinesterase (ACHE) locus was investigated using computational predictive methods and experiments of reverse transcription polymerase chain reaction (RT-PCR). Computational analysis identified two genes downstream to ACHE, an inversely oriented arsenite resistance gene homologue (ARS), and a novel previously unidentified gene (PIX), co-oriented with ACHE. Experimental evidence shows coregulation of murine ACHE and ARS following confined swim, indicating coordinated locus response to stress, that is possibly mediated by altered cholinergic neurotransmission.",

keywords = "ARS, Acetylcholinesterase, Locus response, PIX, Stress response",

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year = "2001",

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AU - Grant, Alastair D.

AU - Shapira, Michael

AU - Soreq, Hermona

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N2 - The mammalian acetylcholinesterase (ACHE) locus was investigated using computational predictive methods and experiments of reverse transcription polymerase chain reaction (RT-PCR). Computational analysis identified two genes downstream to ACHE, an inversely oriented arsenite resistance gene homologue (ARS), and a novel previously unidentified gene (PIX), co-oriented with ACHE. Experimental evidence shows coregulation of murine ACHE and ARS following confined swim, indicating coordinated locus response to stress, that is possibly mediated by altered cholinergic neurotransmission.

AB - The mammalian acetylcholinesterase (ACHE) locus was investigated using computational predictive methods and experiments of reverse transcription polymerase chain reaction (RT-PCR). Computational analysis identified two genes downstream to ACHE, an inversely oriented arsenite resistance gene homologue (ARS), and a novel previously unidentified gene (PIX), co-oriented with ACHE. Experimental evidence shows coregulation of murine ACHE and ARS following confined swim, indicating coordinated locus response to stress, that is possibly mediated by altered cholinergic neurotransmission.

KW - ARS

KW - Acetylcholinesterase

KW - Locus response

KW - PIX

KW - Stress response

UR - https://www.scopus.com/pages/publications/0035565002

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AN - SCOPUS:0035565002

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VL - 21

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EP - 797

JO - Cellular and Molecular Neurobiology

JF - Cellular and Molecular Neurobiology

IS - 6

ER -

Genomic dissection reveals locus response to stress for mammalian acetylcholinesterase

Abstract

Keywords

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