Genomic instability in fragile sites—still adding the pieces

Michal Irony-Tur Sinai, Batsheva Kerem*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Common fragile sites (CFSs) are specific genomic regions in normal chromosomes that exhibit genomic instability under DNA replication stress. As replication stress is an early feature of cancer development, CFSs are involved in the signature of genomic instability found in malignant tumors. The landscape of CFSs is tissue-specific and differs under different replication stress inducers. Nevertheless, the features underlying CFS sensitivity to replication stress are shared. Here, we review the events generating replication stress and discuss the unique characteristics of CFS regions and the cellular responses aimed to stabilizing these regions.

Original languageAmerican English
Pages (from-to)295-304
Number of pages10
JournalGenes Chromosomes and Cancer
Volume58
Issue number5
DOIs
StatePublished - May 2019

Bibliographical note

Publisher Copyright:
© 2018 Wiley Periodicals, Inc.

Keywords

  • AT-dinucleotide rich sequences
  • fragile sites
  • genomic instability
  • replication stress

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