Genomic instability in fragile sites—still adding the pieces

Michal Irony-Tur Sinai; Batsheva Kerem

doi:10.1002/gcc.22715

Genomic instability in fragile sites—still adding the pieces

Michal Irony-Tur Sinai, Batsheva Kerem^*

^*Corresponding author for this work

Department of Genetics

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

Common fragile sites (CFSs) are specific genomic regions in normal chromosomes that exhibit genomic instability under DNA replication stress. As replication stress is an early feature of cancer development, CFSs are involved in the signature of genomic instability found in malignant tumors. The landscape of CFSs is tissue-specific and differs under different replication stress inducers. Nevertheless, the features underlying CFS sensitivity to replication stress are shared. Here, we review the events generating replication stress and discuss the unique characteristics of CFS regions and the cellular responses aimed to stabilizing these regions.

Original language	English
Pages (from-to)	295-304
Number of pages	10
Journal	Genes Chromosomes and Cancer
Volume	58
Issue number	5
DOIs	https://doi.org/10.1002/gcc.22715
State	Published - May 2019

Bibliographical note

Publisher Copyright:
© 2018 Wiley Periodicals, Inc.

Keywords

AT-dinucleotide rich sequences
fragile sites
genomic instability
replication stress

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/gcc.22715

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abstract = "Common fragile sites (CFSs) are specific genomic regions in normal chromosomes that exhibit genomic instability under DNA replication stress. As replication stress is an early feature of cancer development, CFSs are involved in the signature of genomic instability found in malignant tumors. The landscape of CFSs is tissue-specific and differs under different replication stress inducers. Nevertheless, the features underlying CFS sensitivity to replication stress are shared. Here, we review the events generating replication stress and discuss the unique characteristics of CFS regions and the cellular responses aimed to stabilizing these regions.",

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AU - Kerem, Batsheva

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AB - Common fragile sites (CFSs) are specific genomic regions in normal chromosomes that exhibit genomic instability under DNA replication stress. As replication stress is an early feature of cancer development, CFSs are involved in the signature of genomic instability found in malignant tumors. The landscape of CFSs is tissue-specific and differs under different replication stress inducers. Nevertheless, the features underlying CFS sensitivity to replication stress are shared. Here, we review the events generating replication stress and discuss the unique characteristics of CFS regions and the cellular responses aimed to stabilizing these regions.

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KW - replication stress

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Genomic instability in fragile sites—still adding the pieces

Abstract

Bibliographical note

Keywords

UN SDGs

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