Abstract
Common fragile sites (CFSs) are specific genomic regions in normal chromosomes that exhibit genomic instability under DNA replication stress. As replication stress is an early feature of cancer development, CFSs are involved in the signature of genomic instability found in malignant tumors. The landscape of CFSs is tissue-specific and differs under different replication stress inducers. Nevertheless, the features underlying CFS sensitivity to replication stress are shared. Here, we review the events generating replication stress and discuss the unique characteristics of CFS regions and the cellular responses aimed to stabilizing these regions.
| Original language | English |
|---|---|
| Pages (from-to) | 295-304 |
| Number of pages | 10 |
| Journal | Genes Chromosomes and Cancer |
| Volume | 58 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 2019 |
Bibliographical note
Publisher Copyright:© 2018 Wiley Periodicals, Inc.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- AT-dinucleotide rich sequences
- fragile sites
- genomic instability
- replication stress
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