Genomics-Driven Discovery of the Gliovirin Biosynthesis Gene Cluster in the Plant Beneficial Fungus Trichoderma Virens

Pramod D. Sherkhane, Ravindra Bansal, Kaushik Banerjee, Suchandra Chatterjee, Dasharath Oulkar, Prachi Jain, Lea Rosenfelder, Sharona Elgavish, Benjamin A. Horwitz, Prasun K. Mukherjee*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Gliovirin is a strong anti-oomycete and a candidate anticancer compound. It is produced by “P” strains of the plant disease biocontrol fungus Trichoderma virens and is involved in biological control of certain plant pathogens. Even though the compound is known for more than three decades, neither the genes involved nor the biosynthetic pathway are known. We have sequenced the whole genome of a gliovirin producing strain of T. virens and discovered a novel gene cluster comprising of 22 genes. Disruption of the non-ribosomal peptide synthetase eliminated biosynthesis of gliovirin. The gene cluster is very similar to a hitherto un-described gene cluster of Aspergillus udagawae, a human pathogen. Our findings open-up the possibility of strain improvement of T. virens for improved biocontrol of plant diseases through enhanced production of gliovirin. Research also can now be initiated on the role of this gene cluster in pathogenicity of the human pathogen A. udagawae.

Original languageAmerican English
Pages (from-to)3347-3352
Number of pages6
JournalChemistrySelect
Volume2
Issue number11
DOIs
StatePublished - 13 Apr 2017
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

  • Aspergillus
  • Gene Cluster
  • Gliovirin
  • Secondary Metabolite
  • Trichoderma

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