TY - JOUR
T1 - Geometric and many-particle aspects of transmitter binding
AU - Agmon, N.
AU - Edelstein, A. L.
PY - 1995
Y1 - 1995
N2 - We investigate the various reactivity patterns possible when several transmitter molecules, released at one side of a synaptic gap, diffuse and bind reversibly to a single receptor at the other end. In the framework of a one-dimensional approximation, the complete time, reactivity, concentration and gap-width dependence are determined, using a rigorous theoretical and computational approach to the many-body aspects of this problem. The time dependence of the survival probability is found to consist of up to four phases. These include a short delay followed by gaussian, power-law, and exponential decay phases. A rigorous expression is derived for the long-time exponent and approximate expressions are obtained for describing the short-time gaussian phase.
AB - We investigate the various reactivity patterns possible when several transmitter molecules, released at one side of a synaptic gap, diffuse and bind reversibly to a single receptor at the other end. In the framework of a one-dimensional approximation, the complete time, reactivity, concentration and gap-width dependence are determined, using a rigorous theoretical and computational approach to the many-body aspects of this problem. The time dependence of the survival probability is found to consist of up to four phases. These include a short delay followed by gaussian, power-law, and exponential decay phases. A rigorous expression is derived for the long-time exponent and approximate expressions are obtained for describing the short-time gaussian phase.
UR - http://www.scopus.com/inward/record.url?scp=0028918453&partnerID=8YFLogxK
U2 - 10.1016/S0006-3495(95)80258-4
DO - 10.1016/S0006-3495(95)80258-4
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C2 - 7756549
AN - SCOPUS:0028918453
SN - 0006-3495
VL - 68
SP - 815
EP - 825
JO - Biophysical Journal
JF - Biophysical Journal
IS - 3
ER -