TY - JOUR
T1 - Glutathione S-transferase ya subunit is coded by a multigene family located on a single mouse chromosome
AU - Czosnek, H.
AU - Sarid, S.
AU - Barker, P. E.
AU - Ruddle, F. H.
AU - Daniel, V.
PY - 1984/6/25
Y1 - 1984/6/25
N2 - A cloned DNA probe of Ya, the major glutathione S-transferase subunit in rat liver, was used to study the organization of Ya genes in the mouse genome. Southern blot analysis of mouse genomic DNA indicates that the Ya subunit is encoded by a multigene family. The chromosomal distribution of Ya genes was determined by analysis of DNA from a panel of mouse-Chinese hamster somatic cell hybrids. All detectable Ya genes were found to be located on chromosome 9. At least some of the Ya-specific DNA sequences are clustered since, by screening a mouse genomic library, two recombinant phages, each containing two different Ya DNA sequences in the same insert,have been isolated. The finding that Ya is encoded by a cluster of different genes raises the question of the specificity of the different Ya DNA sequences.
AB - A cloned DNA probe of Ya, the major glutathione S-transferase subunit in rat liver, was used to study the organization of Ya genes in the mouse genome. Southern blot analysis of mouse genomic DNA indicates that the Ya subunit is encoded by a multigene family. The chromosomal distribution of Ya genes was determined by analysis of DNA from a panel of mouse-Chinese hamster somatic cell hybrids. All detectable Ya genes were found to be located on chromosome 9. At least some of the Ya-specific DNA sequences are clustered since, by screening a mouse genomic library, two recombinant phages, each containing two different Ya DNA sequences in the same insert,have been isolated. The finding that Ya is encoded by a cluster of different genes raises the question of the specificity of the different Ya DNA sequences.
UR - http://www.scopus.com/inward/record.url?scp=0021770634&partnerID=8YFLogxK
U2 - 10.1093/nar/12.12.4825
DO - 10.1093/nar/12.12.4825
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C2 - 6330685
AN - SCOPUS:0021770634
SN - 0305-1048
VL - 12
SP - 4825
EP - 4833
JO - Nucleic Acids Research
JF - Nucleic Acids Research
IS - 12
ER -