Abstract
This report shows that glutathione affects ascorbic acid degradation in aqueous solution resulting in a significant stabilization of the vitamin. For the GSH concentrations used in this work the effect was higher on diluted ascorbic acid solutions. It is also shown that for a fixed ascorbic acid concentration; as glutathione concentration increases the degradation reaction shifts from first to zero order.
Original language | English |
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Pages (from-to) | 85-88 |
Number of pages | 4 |
Journal | International Journal of Pharmaceutics |
Volume | 133 |
Issue number | 1-2 |
DOIs | |
State | Published - 14 May 1996 |
Keywords
- Ascorbic acid
- Glutathione
- Order of reaction
- Stability in aqueous solution
- Vitamin C degradation