Glutathione stabilizes ascorbic acid in aqueous solution

E. Touitou, M. Alkabes, A. Memoli, F. Alhaique*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

This report shows that glutathione affects ascorbic acid degradation in aqueous solution resulting in a significant stabilization of the vitamin. For the GSH concentrations used in this work the effect was higher on diluted ascorbic acid solutions. It is also shown that for a fixed ascorbic acid concentration; as glutathione concentration increases the degradation reaction shifts from first to zero order.

Original languageEnglish
Pages (from-to)85-88
Number of pages4
JournalInternational Journal of Pharmaceutics
Volume133
Issue number1-2
DOIs
StatePublished - 14 May 1996

Keywords

  • Ascorbic acid
  • Glutathione
  • Order of reaction
  • Stability in aqueous solution
  • Vitamin C degradation

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