Glutathione stabilizes ascorbic acid in aqueous solution

E. Touitou; M. Alkabes; A. Memoli; F. Alhaique

doi:10.1016/0378-5173(95)04419-1

Glutathione stabilizes ascorbic acid in aqueous solution

E. Touitou
, M. Alkabes
, A. Memoli
, F. Alhaique^*

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

This report shows that glutathione affects ascorbic acid degradation in aqueous solution resulting in a significant stabilization of the vitamin. For the GSH concentrations used in this work the effect was higher on diluted ascorbic acid solutions. It is also shown that for a fixed ascorbic acid concentration; as glutathione concentration increases the degradation reaction shifts from first to zero order.

Original language	English
Pages (from-to)	85-88
Number of pages	4
Journal	International Journal of Pharmaceutics
Volume	133
Issue number	1-2
DOIs	https://doi.org/10.1016/0378-5173(95)04419-1
State	Published - 14 May 1996

Keywords

Ascorbic acid
Glutathione
Order of reaction
Stability in aqueous solution
Vitamin C degradation

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10.1016/0378-5173(95)04419-1

Cite this

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abstract = "This report shows that glutathione affects ascorbic acid degradation in aqueous solution resulting in a significant stabilization of the vitamin. For the GSH concentrations used in this work the effect was higher on diluted ascorbic acid solutions. It is also shown that for a fixed ascorbic acid concentration; as glutathione concentration increases the degradation reaction shifts from first to zero order.",

keywords = "Ascorbic acid, Glutathione, Order of reaction, Stability in aqueous solution, Vitamin C degradation",

author = "E. Touitou and M. Alkabes and A. Memoli and F. Alhaique",

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AU - Touitou, E.

AU - Alkabes, M.

AU - Memoli, A.

AU - Alhaique, F.

PY - 1996/5/14

Y1 - 1996/5/14

N2 - This report shows that glutathione affects ascorbic acid degradation in aqueous solution resulting in a significant stabilization of the vitamin. For the GSH concentrations used in this work the effect was higher on diluted ascorbic acid solutions. It is also shown that for a fixed ascorbic acid concentration; as glutathione concentration increases the degradation reaction shifts from first to zero order.

AB - This report shows that glutathione affects ascorbic acid degradation in aqueous solution resulting in a significant stabilization of the vitamin. For the GSH concentrations used in this work the effect was higher on diluted ascorbic acid solutions. It is also shown that for a fixed ascorbic acid concentration; as glutathione concentration increases the degradation reaction shifts from first to zero order.

KW - Ascorbic acid

KW - Glutathione

KW - Order of reaction

KW - Stability in aqueous solution

KW - Vitamin C degradation

UR - https://www.scopus.com/pages/publications/0029896357

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SP - 85

EP - 88

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 1-2

ER -

Glutathione stabilizes ascorbic acid in aqueous solution

Abstract

Keywords

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