Gone with the Wnt/Notch: Stem cells in laminopathies, progeria, and aging

Eran Meshorer*, Yosef Gruenbaum

*Corresponding author for this work

Research output: Contribution to journalComment/debate

62 Scopus citations

Abstract

Specific mutations in the human gene encoding lamin A or in the lamin A-processing enzyme, Zmpste24, cause premature aging. New data on mice and humans suggest that these mutations affect adult stem cells by interfering with the Notch and Wnt signaling pathways.

Original languageAmerican English
Pages (from-to)9-13
Number of pages5
JournalJournal of Cell Biology
Volume181
Issue number1
DOIs
StatePublished - 7 Apr 2008

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