GPCR & company: Databases and servers for GPCRs and interacting partners

Noga Kowalsman, Masha Y. Niv*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

10 Scopus citations


G-protein-coupled receptors (GPCRs) are a large superfamily of membrane receptors that are involved in a wide range of signaling pathways. To fulfill their tasks, GPCRs interact with a variety of partners, including small molecules, lipids and proteins. They are accompanied by different proteins during all phases of their life cycle. Therefore, GPCR interactions with their partners are of great interest in basic cell-signaling research and in drug discovery. Due to the rapid development of computers and internet communication, knowledge and data can be easily shared within the worldwide research community via freely available databases and servers. These provide an abundance of biological, chemical and pharmacological information. This chapter describes the available web resources for investigating GPCR interactions. We review about 40 freely available databases and servers, and provide a few sentences about the essence and the data they supply. For simplification, the databases and servers were grouped under the following topics: general GPCR-ligand interactions; particular families of GPCRs and their ligands; GPCR oligomerization; GPCR interactions with intracellular partners; and structural information on GPCRs. In conclusion, a multitude of useful tools are currently available. Summary tables are provided to ease navigation between the numerous and partially overlapping resources. Suggestions for future enhancements of the online tools include the addition of links from general to specialized databases and enabling usage of user-supplied template for GPCR structural modeling.

Original languageAmerican English
Title of host publicationG Protein-Coupled Receptors - Modeling and Simulation
PublisherSpringer New York LLC
Number of pages20
ISBN (Print)9789400774223
StatePublished - 2014

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598


  • Bitter taste receptors
  • Curation
  • Database cross referencing
  • Databases
  • G protein-coupled receptors
  • Homology
  • Interface
  • Ligand sets
  • Membrane mismatch
  • Models
  • Oligomerization
  • Partners
  • Protein-protein interactions
  • Repository
  • Servers
  • Xray crystallography


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